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Reliable test.

Secure decision.

For expectant parents: Introducing the Harmony® Test

A mother’s blood contains both her own genetic information as well as that of her child, even in the early phases of pregnancy. This so-called “cell-free fetal DNA” (cffDNA) can now be tested for the presence of chromosomal disorders in the unborn child (e.g. trisomies) by means of a simple blood test for the mother.

Thanks to its unique test design, the Harmony® Test is very accurate and at the same time very reasonably priced. The detection rate for trisomy 21 is 99.5%1, and the false-positive rate is only 0.06%2. These figures were determined in a number of clinical studies involving approximately 30,000 pregnant women. These data, obtained with a previous version of the Harmony® Test (next generation sequencing), are fully transferable to the new microarray-based Harmony® Test, which has an even higher precision3. A recent study of the Harmony® Test based on the microarray technology, shows a detection rate of >99 % for trisomy 21 and a detection of all trisomy 18 and 13 cases. There were no false-positive results4.

Further details are available on the page Harmony® Test.

If you would like to have further information material this can be downloaded directly in our download area.

  1. Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1 ↩
  2. Norton ME ,Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ and Wapner RJ: Cell-free DNA Analysis for Noninvasive Examination of Trisomy. N Engl J Med. 2015, Apr 1, DOI: 10.1056/NEJMoa1407349 ↩
  3. Juneau K, Bogard PE, Huang S, Mohseni M, Wang ET, Ryvkin P, Kingsley C, Struble CA, Oliphant A, Zahn JM: Microarray-based cell-free DNA analysis improves noninvasive prenatal testing. Fetal Diagn Ther. 2014;36(4):282-6. doi: 10.1159/000367626 . Epub 2014 Sep 12. ↩
  4. Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1 ↩

For expectant parents

  • For expectant parents
  • Harmony® Test procedure
  • Understanding the results
  • Information on numerical chromosomal disorders
  • Information on X and Y chromosomal disorders
  • DiGeorge syndrome (Microdeletion 22q11.2)
  • Reimbursement of costs
  • Useful links for parents
  • Downloads
  • FAQ

Search

About Cenata

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  • Quality Management
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