{"id":4848,"date":"2020-12-09T09:48:34","date_gmt":"2020-12-09T08:48:34","guid":{"rendered":"https:\/\/www.cenata.de\/?p=4848"},"modified":"2022-05-02T08:53:10","modified_gmt":"2022-05-02T07:53:10","slug":"confirmation-rate-ppv-of-screening-for-sex-chromosomal-abnormalities-with-the-harmony-test-depends-on-the-method-of-confirmatory-testing","status":"publish","type":"post","link":"https:\/\/www.cenata.de\/en\/confirmation-rate-ppv-of-screening-for-sex-chromosomal-abnormalities-with-the-harmony-test-depends-on-the-method-of-confirmatory-testing\/","title":{"rendered":"Confirmation rate (PPV) of screening for sex chromosomal abnormalities with the Harmony Test depends on the method of confirmatory testing"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4848\" class=\"elementor elementor-4848\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ed23d7 elementor-section-stretched elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ed23d7\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2fb61e0 elementor-hidden-mobile\" data-id=\"2fb61e0\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1ace658 elementor-nav-menu__align-end elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"1ace658\" 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class=\"menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-23306\"><a href=\"https:\/\/www.cenata.de\/en\/news-2\/\" class=\"elementor-item menu-link\">Latest news<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-1ace658\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-28005\"><a href=\"https:\/\/www.cenata.de\/en\/about-cenata\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Team Cenata<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23127\"><a href=\"https:\/\/www.cenata.de\/en\/quality-management\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Quality Management<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page current_page_parent menu-item-23306\"><a href=\"https:\/\/www.cenata.de\/en\/news-2\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Latest news<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9130cbc\" data-id=\"9130cbc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34205f1 elementor-widget elementor-widget-heading\" data-id=\"34205f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Confirmation rate (PPV) of screening for sex chromosomal abnormalities with the Harmony Test depends on the method of confirmatory testing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba15763 elementor-widget elementor-widget-text-editor\" data-id=\"ba15763\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\">9. December 2020<\/header><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f1e1c0 elementor-widget elementor-widget-text-editor\" data-id=\"8f1e1c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><div id=\"footnotes-5402\" class=\"footnotes\"><div class=\"entry-content\"><p>In a current study in collaboration with Prof. Oliver Kagan (University Hospital T&uuml;bingen) and Francesca Grati (TOMA Advanced Biomedical Assays SpA, Impact Lab Group), published in&nbsp;<a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/journal\/10970223\" target=\"_blank\" rel=\"nofollow noopener\">Prenatal Diagnosis<\/a>&nbsp;in August 2020, the&nbsp;<a class=\"encyclopedia\" title=\"The PPV reflects the rate of positive test results that are confirmed by chromosome analysis or after birth. The risk of the presence of a fetal trisomy 21 during pregnancy is approximately 1:500 for the average population. Almost all of these cases are correctly detected by the Harmony&reg; test (detection rate 99.3%[1.Stokowski R, Wang E,&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/positive-predictive-value-ppv\/\" target=\"_self\">positive predictive value (PPV)<\/a>&nbsp;in screening for gonosomal aneuploidies (sex chromosomal aneuploidies [SCA]) was determined.<\/p><p>More than 90,000 pregnant women were examined by Cenata for an XY-linked disorder using the Roche\/Ariosa Harmony&nbsp;<sup>&reg;<\/sup>&nbsp;Test. In 351 (0.53%) of 66,203 evaluable&nbsp;<a class=\"encyclopedia\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\">cfDNA<\/a>&nbsp;tests for SCA, an abnormal result was obtained. The study population consisted of 144 pregnant women who had opted for prenatal karyotyping using AC or CVS or a postnatal examination. Amniocentesis was performed in 78 cases and&nbsp;<a class=\"encyclopedia\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\">chorionic villus sampling<\/a>&nbsp;in 34 cases. Postnatal karyotyping was performed in 32 pregnancies.<\/p><p>38.9% of the high risk <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> tests for SCA were confirmed by CVS \/ AC or postnatal examination. In particular, the confirmation rate for&nbsp;<a class=\"encyclopedia\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\">monosomy X<\/a>&nbsp;(MX) was significantly dependent on the diagnostic test method used: While CVS confirmed 54.6% of the abnormal <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> tests for MX, only 17.1% were confirmed with AC (chi-square test p = 0.014).<\/p><p>The confirmation rate or the PPV of an abnormal <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> result for SCA is thus significantly lower than for&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\">trisomy 21<\/a>, 18 or 13. This is especially the case for a&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" class=\"encyclopedia\">monosomy X<\/a>. The method of choice for examining the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> karyotype should, especially in case of an increased risk of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" class=\"encyclopedia\">monosomy X<\/a>, be amniocentesis and not <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" class=\"encyclopedia\">chorionic villus sampling<\/a>.<\/p><p>Read the full article&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32804406\" target=\"_blank\" rel=\"nofollow noopener\">here<\/a>.<\/p><\/div><p>&nbsp;<\/p><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-99d4a7a elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"99d4a7a\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a09427f\" data-id=\"a09427f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86c55d7 elementor-widget elementor-widget-heading\" data-id=\"86c55d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Confirmation rate (PPV) of screening for sex chromosomal abnormalities with the Harmony Test depends on the method of confirmatory testing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-caac59d elementor-widget elementor-widget-text-editor\" data-id=\"caac59d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\">9. December 2020<\/header><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6768705 elementor-widget elementor-widget-text-editor\" data-id=\"6768705\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><div id=\"footnotes-5402\" class=\"footnotes\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><div id=\"footnotes-5402\" class=\"footnotes\"><div class=\"entry-content\"><p>In a current study in collaboration with Prof. Oliver Kagan (University Hospital T&uuml;bingen) and Francesca Grati (TOMA Advanced Biomedical Assays SpA, Impact Lab Group), published in&nbsp;<a href=\"https:\/\/obgyn.onlinelibrary.wiley.com\/journal\/10970223\" target=\"_blank\" rel=\"nofollow noopener\">Prenatal Diagnosis<\/a>&nbsp;in August 2020, the&nbsp;<a class=\"encyclopedia\" title=\"The PPV reflects the rate of positive test results that are confirmed by chromosome analysis or after birth. The risk of the presence of a fetal trisomy 21 during pregnancy is approximately 1:500 for the average population. Almost all of these cases are correctly detected by the Harmony&reg; test (detection rate 99.3%[1.Stokowski R, Wang E,&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/positive-predictive-value-ppv\/\" target=\"_self\">positive predictive value (PPV)<\/a>&nbsp;in screening for gonosomal aneuploidies (sex chromosomal aneuploidies [SCA]) was determined.<\/p><p>More than 90,000 pregnant women were examined by Cenata for an XY-linked disorder using the Roche\/Ariosa Harmony&nbsp;<sup>&reg;<\/sup>&nbsp;Test. In 351 (0.53%) of 66,203 evaluable&nbsp;<a class=\"encyclopedia\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\">cfDNA<\/a>&nbsp;tests for SCA, an abnormal result was obtained. The study population consisted of 144 pregnant women who had opted for prenatal karyotyping using AC or CVS or a postnatal examination. Amniocentesis was performed in 78 cases and&nbsp;<a class=\"encyclopedia\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\">chorionic villus sampling<\/a>&nbsp;in 34 cases. Postnatal karyotyping was performed in 32 pregnancies.<\/p><p>38.9% of the high risk <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> tests for SCA were confirmed by CVS \/ AC or postnatal examination. In particular, the confirmation rate for&nbsp;<a class=\"encyclopedia\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\">monosomy X<\/a>&nbsp;(MX) was significantly dependent on the diagnostic test method used: While CVS confirmed 54.6% of the abnormal <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> tests for MX, only 17.1% were confirmed with AC (chi-square test p = 0.014).<\/p><p>The confirmation rate or the PPV of an abnormal <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> result for SCA is thus significantly lower than for&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\">trisomy 21<\/a>, 18 or 13. This is especially the case for a&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" class=\"encyclopedia\">monosomy X<\/a>. The method of choice for examining the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> karyotype should, especially in case of an increased risk of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/monosomy-x\/\" target=\"_self\" title=\"This disorder is also known as Ullrich-Turner syndrome. The somatic cells of affected girls contain only one functioning X-chromosome instead of two sex chromosomes (XX).\" class=\"encyclopedia\">monosomy X<\/a>, be amniocentesis and not <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" class=\"encyclopedia\">chorionic villus sampling<\/a>.<\/p><p>Read the full article&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32804406\" target=\"_blank\" rel=\"nofollow noopener\">here<\/a>.<\/p><\/div><\/div><\/div><\/header><\/header><\/header><\/header><\/header><p>&nbsp;<\/p><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header><\/div><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header><\/header><\/header><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Confirmation rate (PPV) of screening for sex chromosomal abnormalities with the Harmony Test depends on the method of confirmatory testing 9. December 2020 In a current study in collaboration with Prof. Oliver Kagan (University Hospital T\u00fcbingen) and Francesca Grati (TOMA Advanced Biomedical Assays SpA, Impact Lab Group), published in\u00a0Prenatal Diagnosis\u00a0in August 2020, the\u00a0positive predictive value [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4848","post","type-post","status-publish","format-standard","hentry","category-unkategorisiert"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/4848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/comments?post=4848"}],"version-history":[{"count":10,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/4848\/revisions"}],"predecessor-version":[{"id":24990,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/4848\/revisions\/24990"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=4848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/categories?post=4848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/tags?post=4848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}