{"id":22837,"date":"2022-03-28T16:57:32","date_gmt":"2022-03-28T14:57:32","guid":{"rendered":"https:\/\/www.cenata.de\/?p=20290"},"modified":"2022-05-02T08:49:04","modified_gmt":"2022-05-02T07:49:04","slug":"discontinuation-of-the-test-option-microdeletion-22q11-2-digeorge-syndrome","status":"publish","type":"post","link":"https:\/\/www.cenata.de\/en\/discontinuation-of-the-test-option-microdeletion-22q11-2-digeorge-syndrome\/","title":{"rendered":"Discontinuation of the test option microdeletion 22q11.2 (DiGeorge syndrome)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22837\" class=\"elementor elementor-22837\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0a5cacd elementor-section-stretched elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0a5cacd\" 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class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Discontinuation of the test option microdeletion 22q11.2 (DiGeorge syndrome)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d19604 elementor-widget elementor-widget-text-editor\" data-id=\"4d19604\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><p>28. March 2022<\/p><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da4cff2 elementor-widget elementor-widget-text-editor\" data-id=\"da4cff2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><p>We have been analyzing the 22q11.2 <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2 (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>) as part of the Harmony<sup>&reg;<\/sup>&nbsp;Test since July 2018. We now evaluated the data from more than 50000 cases.<\/p><p>The evaluation of the data shows that of the cases tested positive for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a> with our Harmony<sup>&reg;<\/sup>&nbsp;Test, only 5.4% were confirmed. Thus, our own data support the current publication record, based on a wide variety of&nbsp;<a class=\"encyclopedia\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>&nbsp;technologies, on the low PPV of screening for&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2 by <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> [1]. In our study, additional testing for the 22q11.2 <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> increased the positive rate by 0.47 percentage points to over 0.5%. For testing for trisomies 21, 18 and 13 alone, the false positive rate of the Harmony<sup>&reg;<\/sup>&nbsp;Test is less than 0.1%.<\/p><p>These results underline the statement of the working group around Prof. Nicolaides [2] that extending testing to <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s other than 13, 18 and 21 significantly increases the test positive rate by 0.4-0.8%. In addition, our data also support the statement by DEGUM that the use of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a>, particularly for screening for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>s, is currently not recommended [3].<\/p><p>Based on the above results, we have decided to remove the test option &ldquo;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">Microdeletion<\/a> 22q11.2 \/ <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>&rdquo; from our test portfolio and will no longer offer it as of 04\/01\/2022.<\/p><p>You are welcome to continue using any existing request forms. You can also&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/services\/downloads\/\"><u>download<\/u><\/a>&nbsp;or request new forms by&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/services\/order-sampling-kit\/\"><u>contacting<\/u><\/a>&nbsp;us.<\/p><p>&nbsp;<\/p><h6>&nbsp;<\/h6><h6>Literatur:<\/h6><h6>[1] Martin K, Iyengar S, Kalyan A, et al (2017) Clinical Experience with a Single&#8208;Nucleotide Polymorphism&#8208;Based Noninvasive Prenatal Test for Five<br>Clinically Significant Microdeletions. Clinical genetics. doi.org\/10.1111\/cge.13098<\/h6><h6>[2] Jani JC, Gil MM, Benachi A et al, Genome-wide cfDNA testing of maternal blood, Ultrasound Obstet Gynecol. 2020;55:13-14<\/h6><h6>[3] https:\/\/www.degum.de\/fileadmin\/dokumente\/sektionen\/gynaekologie\/Informationen_zum_Fach\/NIPT-10-goldene-Regeln_AK_v2020-02-17.pdf<\/h6><\/div><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-25add60 elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"25add60\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2d4029e\" data-id=\"2d4029e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab7a734 elementor-widget elementor-widget-heading\" data-id=\"ab7a734\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Discontinuation of the test option microdeletion 22q11.2 (DiGeorge syndrome)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3d8248 elementor-widget elementor-widget-text-editor\" data-id=\"c3d8248\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><p>28. March 2022<\/p><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b470f9b elementor-widget elementor-widget-text-editor\" data-id=\"b470f9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><div class=\"entry-content\"><p>We have been analyzing the 22q11.2 <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2 (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>) as part of the Harmony<sup>&reg;<\/sup>&nbsp;Test since July 2018. We now evaluated the data from more than 50000 cases.<\/p><p>The evaluation of the data shows that of the cases tested positive for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a> with our Harmony<sup>&reg;<\/sup>&nbsp;Test, only 5.4% were confirmed. Thus, our own data support the current publication record, based on a wide variety of&nbsp;<a class=\"encyclopedia\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>&nbsp;technologies, on the low PPV of screening for&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2 by <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> [1]. In our study, additional testing for the 22q11.2 <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> increased the positive rate by 0.47 percentage points to over 0.5%. For testing for trisomies 21, 18 and 13 alone, the false positive rate of the Harmony<sup>&reg;<\/sup>&nbsp;Test is less than 0.1%.<\/p><p>These results underline the statement of the working group around Prof. Nicolaides [2] that extending testing to <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s other than 13, 18 and 21 significantly increases the test positive rate by 0.4-0.8%. In addition, our data also support the statement by DEGUM that the use of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a>, particularly for screening for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>s, is currently not recommended [3].<\/p><p>Based on the above results, we have decided to remove the test option &ldquo;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">Microdeletion<\/a> 22q11.2 \/ <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>&rdquo; from our test portfolio and will no longer offer it as of 04\/01\/2022.<\/p><p>You are welcome to continue using any existing request forms. You can also&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/services\/downloads\/\"><u>download<\/u><\/a>&nbsp;or request new forms by&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/services\/order-sampling-kit\/\"><u>contacting<\/u><\/a>&nbsp;us.<\/p><h6>Literatur:<\/h6><h6>[1] Martin K, Iyengar S, Kalyan A, et al (2017) Clinical Experience with a Single&#8208;Nucleotide Polymorphism&#8208;Based Noninvasive Prenatal Test for Five<br>Clinically Significant Microdeletions. Clinical genetics. doi.org\/10.1111\/cge.13098<\/h6><h6>[2] Jani JC, Gil MM, Benachi A et al, Genome-wide cfDNA testing of maternal blood, Ultrasound Obstet Gynecol. 2020;55:13-14<\/h6><h6>[3] https:\/\/www.degum.de\/fileadmin\/dokumente\/sektionen\/gynaekologie\/Informationen_zum_Fach\/NIPT-10-goldene-Regeln_AK_v2020-02-17.pdf<\/h6><h6>&nbsp;<\/h6><\/div><footer class=\"entry-footer\"><\/footer><\/header><\/header><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Discontinuation of the test option microdeletion 22q11.2 (DiGeorge syndrome) 28. March 2022 We have been analyzing the 22q11.2 microdeletion 22q11.2 (DiGeorge syndrome) as part of the Harmony\u00ae\u00a0Test since July 2018. We now evaluated the data from more than 50000 cases. The evaluation of the data shows that of the cases tested positive for DiGeorge syndrome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-22837","post","type-post","status-publish","format-standard","hentry","category-unkategorisiert"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/22837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/comments?post=22837"}],"version-history":[{"count":7,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/22837\/revisions"}],"predecessor-version":[{"id":24969,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/posts\/22837\/revisions\/24969"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=22837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/categories?post=22837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/tags?post=22837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}