{"id":600,"date":"2016-11-12T07:34:12","date_gmt":"2016-11-12T06:34:12","guid":{"rendered":"https:\/\/cegat.net\/web\/en\/for-physicians\/ablauf-des-harmony-tests\/"},"modified":"2026-02-25T13:03:58","modified_gmt":"2026-02-25T12:03:58","slug":"harmony-test-procedure","status":"publish","type":"page","link":"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/","title":{"rendered":"Harmony\u00ae Test procedure"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"600\" class=\"elementor elementor-600\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a19e77e elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a19e77e\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cdc9254\" data-id=\"cdc9254\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bfd83da elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"bfd83da\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0bfef80 elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0bfef80\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc8e22e\" data-id=\"cc8e22e\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ac8f19 elementor-hidden-mobile elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ac8f19\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-82ee3b0\" data-id=\"82ee3b0\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bb3698c elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"bb3698c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-53946e3 elementor-hidden-mobile elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"53946e3\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-09a8635\" data-id=\"09a8635\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-39c5337 elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39c5337\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-de23421\" data-id=\"de23421\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d484aa5 elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"d484aa5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-34014c7 elementor-hidden-tablet elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"34014c7\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-96e3b8f\" data-id=\"96e3b8f\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c02ac6c elementor-section-stretched elementor-hidden-mobile elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c02ac6c\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2978ed0 elementor-hidden-mobile\" data-id=\"2978ed0\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90a75ef elementor-widget elementor-widget-heading\" data-id=\"90a75ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR PHYSICIANS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b265841 elementor-nav-menu__align-end elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"b265841\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Men&uuml;\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-b265841\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-b265841\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3ac3bc elementor-widget elementor-widget-heading\" data-id=\"c3ac3bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9575b5 elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"d9575b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-d9575b5\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-d9575b5\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5e049c8\" data-id=\"5e049c8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c05635 elementor-widget elementor-widget-heading\" data-id=\"2c05635\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Harmony&reg; Test procedure<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8bd8c9f elementor-widget elementor-widget-text-editor\" data-id=\"8bd8c9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed from week 10+0 of the pregnancy. Before carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, the patient should be given an ultrasound scan to determine the gestational age and to check whether it is a singleton or multiple pregnancy.<\/p><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a551d20 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a551d20\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-09ed344\" data-id=\"09ed344\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c11b00d elementor-widget elementor-widget-image\" data-id=\"c11b00d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"723\" height=\"1024\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg\" class=\"attachment-large size-large wp-image-21969\" alt=\"Test procedure\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg 723w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-212x300.jpg 212w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-768x1088.jpg 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1085x1536.jpg 1085w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1446x2048.jpg 1446w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN.jpg 1557w\" sizes=\"(max-width: 723px) 100vw, 723px\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b878f6 elementor-widget elementor-widget-toggle\" data-id=\"7b878f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1291\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1291\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Requirements for the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1291\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1291\">The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed with all singleton or twin pregnancies, irrespective of the manner of conception (including&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>). Data indicates that the detection rate for twin pregnancies (93%) is slightly lower than for singleton pregnancies.<sup class=\"footnote\"><a id=\"fnref-600-1\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-1\">1<\/a><\/sup>,<sup class=\"footnote\"><a id=\"fnref-600-2\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-2\">2<\/a><\/sup>&nbsp;It is not yet possible to test twin pregnancies for sex&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;anomalies (X, Y) such as Turner or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/klinefelter-syndrome\/\" target=\"_self\" title=\"This chromosomal disorder affects males and is characterised by an extra X-chromosome in all, or in a proportion, of the cells of the body. Further information about Klinefelter syndrome can be found here.\" class=\"encyclopedia\">Klinefelter syndrome<\/a>s and the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>.\n\nThe table below provides an overview of which Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible with different types of pregnancies.\n<table>\n<thead>\n<tr>\n<td><\/td>\n<td><center>Singleton pregnancies incl. all IVF pregnancies<\/center><\/td>\n<td><center>Twin pregnancies incl. all IVF pregnancies<\/center><\/td>\n<td><center>More than two fetuses<\/center><\/td>\n\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Harmony<sup>&reg;<\/sup>&nbsp;Test<\/td>\n<td><center><img decoding=\"async\" class=\"size-full wp-image-21989 aligncenter\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img decoding=\"async\" class=\"alignnone size-full wp-image-21989\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n\n<\/tr>\n<tr>\n<td>Harmony<sup>&reg;<\/sup>&nbsp;with with X\/Y analysis<\/td>\n<td><center><img decoding=\"async\" class=\"alignnone size-full wp-image-21989\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a><\/td>\n<td><center><img decoding=\"async\" class=\"alignnone size-full wp-image-21989\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n\n<\/tr>\n<tr>\n<td>sex determination<\/td>\n<td><center><img decoding=\"async\" class=\"alignnone size-full wp-image-21989\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img decoding=\"async\" class=\"alignnone size-full wp-image-21989\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"\" width=\"25\" height=\"27\"><\/center><\/td>\n<td><center><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-21990\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"\" width=\"19\" height=\"19\"><\/center><\/td>\n\n<\/tr>\n<\/tbody>\n<\/table>\nAn important requirement for the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test is detailed, open and objective patient counseling in accordance with the German Genetic Diagnostics Act. If the patient decides to take the test, 2 x 9 ml of venous blood should be drawn into special blood tubes (provided). After the request form has been fully completed, the two blood tubes should be packed as described in the instructions (included in the sampling kit) and sent by post or courier.\n\nThe cell-free&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;remains stable for approximately 9 days in the special test tubes. Cenata will only accept samples that are not more than 7 days old. The samples should thus be sent as quickly as possible after the blood draw. The samples should stay at room temperature and never be cooled or frozen since haemolysis will occur, and the test cannot be analysed.\n\nThe test is evaluated using CE-certified software.\n\nOn average it takes 3 working days from its receipt to process the sample until the results are returned. This means that you will usually have the results for your patient on the 5th working day after the blood sample was taken.\n\nIf the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is to be determined during the test, the patient may only be informed of this after week 12+0 of the pregnancy in accordance with the Genetic Diagnostics Act (post-conception, corresponding to week 14 of the pregnancy when calculated starting after the last period). If the patient is not yet in week 14+0 of the pregnancy when the results are ready we will send you (the requesting physician) partial findings that do not contain information on the sex of the fetus. When week 14+0 of the pregnancy is reached we will automatically send you the report on the sex of the fetus.<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1292\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1292\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quality parameters of the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1292\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1292\"><p>Each patient sample undergoes a multi-stage quality control process in our laboratory.<\/p><p>The first quality control takes place directly at the sample entrance. Here it is determined whether the durability, the duration of transport, the information on the request form as well as the quantity and consistency of the sample meet the specified quality requirements.<br>During processing in the laboratory, each analysis must pass a variety of quality control criteria. These are listed in the overview below:<\/p><table><tbody><tr><td width=\"149\"><strong>Parameter<\/strong><\/td><td width=\"465\"><strong>Description<\/strong><\/td><\/tr><tr><td width=\"149\"><strong>Array Quality<\/strong><\/td><td width=\"465\">General&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;quality<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction<\/strong><\/td><td width=\"465\">Amount of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> relative to maternal cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a><\/td><\/tr><tr><td width=\"149\"><strong>Signal<\/strong><\/td><td width=\"465\">Signal intensity of the measurement<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> Quality<\/strong><\/td><td width=\"465\">Indication of the overall quality of the analysis. Indication of another <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> species in the sample.<\/td><\/tr><tr><td width=\"149\"><strong>Noise<\/strong><\/td><td width=\"465\">Intensity of the background signal<\/td><\/tr><tr><td width=\"149\"><strong>Signal to Noise<\/strong><\/td><td width=\"465\">Indication of the ratio of the signal intensity to the background signal<\/td><\/tr><\/tbody><\/table><p>Only when all parameters reach a minimum value, an analysis result is recieved, and the detailed report is created.<\/p><p>This is followed by the third stage of result release &ndash; medical validation. Each report is reviewed and approved by a team of qualified physicians and scientists.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1293\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1293\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reasons for test failure<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1293\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1293\"><p>In a small number of cases, the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>) in the blood may be too low for results to be obtained. In these cases, Cenata will automatically repeat the test. If no clear results are obtained from the repeat test, the report will be returned as &ldquo;not analysable&rdquo; and Cenata will not charge the patient for the test. A new blood sample may be submitted at a slightly later date, as the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction) in the mother&rsquo;s blood increases with the length of the pregnancy.<\/p><p><a href=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-606 size-full\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\" alt=\"\" width=\"1432\" height=\"809\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg 1432w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-300x169.jpg 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-1024x579.jpg 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-768x434.jpg 768w\" sizes=\"(max-width: 1432px) 100vw, 1432px\"><\/a> Figure 1: Relationship of the &ldquo;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction&rdquo; and the week of pregnancy (<a class=\"encyclopedia\" title=\"Schwangerschaftswoche (German for \" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/ssw\/\" target=\"_self\">SSW<\/a>) (modified acc. to&nbsp;<sup class=\"footnote\"><a id=\"fnref-600-3\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-3\">3<\/a><\/sup>)<\/p><div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-7 el_after_av_one_half avia-builder-el-last column-top-margin\"><div class=\"togglecontainer toggle_close_all avia-builder-el-8 avia-builder-el-no-sibling enable_toggles\"><section class=\"av_toggle_section\"><div class=\"single_toggle\" data-tags=\"{Alle} \"><div id=\"toggle-id-3-container\" class=\"toggle_wrap active_tc\"><div class=\"toggle_content invers-color \"><p>Other reasons why the test may fail include the existence of an egg donation about which we were not informed, a &ldquo;vanishing twin&rdquo; situation, or previously unknown maternal chromosomal disorders.<\/p><p>If you need help interpreting the findings or have any questions on the methods used in the Harmony<sup>&reg;<\/sup>&nbsp;Test, you can consult our team of qualified physicians including specialists in human genetics, laboratory medicine and obstetrics\/gynaecology.<\/p><p>Free kits with the CE-labelled blood collection tubes for the blood samples and the transport material can be ordered in the following ways:<\/p><ul><li>using our&nbsp;<a title=\"Contact\" href=\"https:\/\/www.cenata.de\/en\/contact\/\">contact form<\/a><\/li><li>by fax: +49 7071 565 44 444<\/li><li>by phone +49 7071 565 44 430<\/li><\/ul><p>The order request form to be completed by the patient is included with the sampling kit and can also be downloaded from our homepage.<\/p><\/div><\/div><\/div><\/section><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24b2b73 elementor-widget elementor-widget-text-editor\" data-id=\"24b2b73\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464\" target=\"_blank\" rel=\"noopener\">Bevilacqua E, Gil MM, Nicolaides KH, Ordo&ntilde;ez E, Cirigliano V, Dierickx H, Willems PJ, Jani JC.&nbsp;<span lang=\"en-US\">Performance of screening for aneuploidies by cell-free DNA analysis of maternal blood in twin pregnancies.&nbsp;<\/span>Ultrasound Obstet Gynecol. 2015 Jan;45(1):61-6. doi: 10.1002\/uog.14690. Epub 2014 Dec 4.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-600-2\"><span lang=\"en-US\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24247435\" target=\"_blank\" rel=\"noopener\">del Mar Gil M, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free DNA analysis for trisomy risk assessment in first-trimester twin pregnancies. Fetal Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-2\">&#8617;<\/a><\/span><\/span><\/li><li id=\"fn-600-3\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23553731\" target=\"_blank\" rel=\"noopener\">Wang E1, Batey A, Struble C, Musci T, Song K, Oliphant A. Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma. Prenat Diagn. 2013 Jul;33(7):662-6. doi: 10.1002\/pd.4119. Epub 2013 May 9.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-3\">&#8617;<\/a><\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2cb5e41 elementor-hidden-mobile elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2cb5e41\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-a7c9a30 elementor-hidden-mobile\" data-id=\"a7c9a30\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13ba4e2 elementor-widget elementor-widget-heading\" data-id=\"13ba4e2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR PHYSICIANS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28d3193 elementor-nav-menu__align-end elementor-nav-menu--dropdown-mobile elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"28d3193\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Men&uuml;\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-28d3193\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-28d3193\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9add314 elementor-widget elementor-widget-heading\" data-id=\"9add314\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c27d45 elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"9c27d45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-9c27d45\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-9c27d45\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-110dec2\" data-id=\"110dec2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0581089 elementor-widget elementor-widget-heading\" data-id=\"0581089\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Harmony&reg; Test procedure<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9d1835 elementor-widget elementor-widget-text-editor\" data-id=\"b9d1835\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed from week 10+0 of the pregnancy. Before carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, the patient should be given an ultrasound scan to determine the gestational age and to check whether it is a singleton or multiple pregnancy.<\/p><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a5a0e42 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a5a0e42\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-ab83cbf\" data-id=\"ab83cbf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4c634a8 elementor-widget elementor-widget-image\" data-id=\"4c634a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"723\" height=\"1024\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg\" class=\"attachment-large size-large wp-image-21969\" alt=\"Test procedure\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg 723w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-212x300.jpg 212w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-768x1088.jpg 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1085x1536.jpg 1085w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1446x2048.jpg 1446w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN.jpg 1557w\" sizes=\"(max-width: 723px) 100vw, 723px\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-177991e elementor-widget elementor-widget-toggle\" data-id=\"177991e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2461\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2461\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Requirements for the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2461\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2461\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed with all singleton or twin pregnancies, irrespective of the manner of conception (including&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>). Data indicates that the detection rate for twin pregnancies (93%) is slightly lower than for singleton pregnancies.<sup class=\"footnote\"><a id=\"fnref-600-1\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-1\">1<\/a><\/sup>,<sup class=\"footnote\"><a id=\"fnref-600-2\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-2\">2<\/a><\/sup>&nbsp;It is not yet possible to test twin pregnancies for sex&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;anomalies (X, Y) such as Turner or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/klinefelter-syndrome\/\" target=\"_self\" title=\"This chromosomal disorder affects males and is characterised by an extra X-chromosome in all, or in a proportion, of the cells of the body. Further information about Klinefelter syndrome can be found here.\" class=\"encyclopedia\">Klinefelter syndrome<\/a>s and the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>.<\/p><p>The table below provides an overview of which Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible with different types of pregnancies.<br>\n<\/p><table id=\"tablepress-3\" class=\"tablepress tablepress-id-3\">\n<tbody>\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><\/td><td class=\"column-2\">Singleton pregnancies incl. all IVF pregnancies<\/td><td class=\"column-3\">Twin pregnancies incl. all IVF pregnancies<\/td><td class=\"column-4\">More than two fetuses<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Harmony&reg; Test<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Harmony&reg; with with X\/Y analysis<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a><\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">sex determination<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>An important requirement for the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test is detailed, open and objective patient counseling in accordance with the German Genetic Diagnostics Act. If the patient decides to take the test, 2 x 9 ml of venous blood should be drawn into special blood tubes (provided). After the request form has been fully completed, the two blood tubes should be packed as described in the instructions (included in the sampling kit) and sent by post or courier.<\/p><p>The cell-free&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;remains stable for approximately 9 days in the special test tubes. Cenata will only accept samples that are not more than 7 days old. The samples should thus be sent as quickly as possible after the blood draw. The samples should stay at room temperature and never be cooled or frozen since haemolysis will occur, and the test cannot be analysed.<\/p><p>The test is evaluated using CE-certified software.<\/p><p>On average it takes 3 working days from its receipt to process the sample until the results are returned. This means that you will usually have the results for your patient on the 5th working day after the blood sample was taken.<\/p><p>If the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is to be determined during the test, the patient may only be informed of this after week 12+0 of the pregnancy in accordance with the Genetic Diagnostics Act (post-conception, corresponding to week 14 of the pregnancy when calculated starting after the last period). If the patient is not yet in week 14+0 of the pregnancy when the results are ready we will send you (the requesting physician) partial findings that do not contain information on the sex of the fetus. When week 14+0 of the pregnancy is reached we will automatically send you the report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2462\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2462\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quality parameters of the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2462\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2462\"><p>Each patient sample undergoes a multi-stage quality control process in our laboratory.<\/p><p>The first quality control takes place directly at the sample entrance. Here it is determined whether the durability, the duration of transport, the information on the request form as well as the quantity and consistency of the sample meet the specified quality requirements.<br>During processing in the laboratory, each analysis must pass a variety of quality control criteria. These are listed in the overview below:<\/p><table><tbody><tr><td width=\"149\"><strong>Parameter<\/strong><\/td><td width=\"465\"><strong>Description<\/strong><\/td><\/tr><tr><td width=\"149\"><strong>Array Quality<\/strong><\/td><td width=\"465\">General&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;quality<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction<\/strong><\/td><td width=\"465\">Amount of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> relative to maternal cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a><\/td><\/tr><tr><td width=\"149\"><strong>Signal<\/strong><\/td><td width=\"465\">Signal intensity of the measurement<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> Quality<\/strong><\/td><td width=\"465\">Indication of the overall quality of the analysis. Indication of another <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> species in the sample.<\/td><\/tr><tr><td width=\"149\"><strong>Noise<\/strong><\/td><td width=\"465\">Intensity of the background signal<\/td><\/tr><tr><td width=\"149\"><strong>Signal to Noise<\/strong><\/td><td width=\"465\">Indication of the ratio of the signal intensity to the background signal<\/td><\/tr><\/tbody><\/table><p>Only when all parameters reach a minimum value, an analysis result is recieved, and the detailed report is created.<\/p><p>This is followed by the third stage of result release &ndash; medical validation. Each report is reviewed and approved by a team of qualified physicians and scientists.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2463\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2463\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reasons for test failure<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2463\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2463\"><p>In a small number of cases, the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>) in the blood may be too low for results to be obtained. In these cases, Cenata will automatically repeat the test. If no clear results are obtained from the repeat test, the report will be returned as &ldquo;not analysable&rdquo; and Cenata will not charge the patient for the test. A new blood sample may be submitted at a slightly later date, as the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction) in the mother&rsquo;s blood increases with the length of the pregnancy.<\/p><p><a href=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-606 size-full\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\" alt=\"\" width=\"1432\" height=\"809\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg 1432w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-300x169.jpg 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-1024x579.jpg 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-768x434.jpg 768w\" sizes=\"(max-width: 1432px) 100vw, 1432px\"><\/a> Figure 1: Relationship of the &ldquo;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction&rdquo; and the week of pregnancy (<a class=\"encyclopedia\" title=\"Schwangerschaftswoche (German for \" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/ssw\/\" target=\"_self\">SSW<\/a>) (modified acc. to&nbsp;<sup class=\"footnote\"><a id=\"fnref-600-3\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-3\">3<\/a><\/sup>)<\/p><div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-7 el_after_av_one_half avia-builder-el-last column-top-margin\"><div class=\"togglecontainer toggle_close_all avia-builder-el-8 avia-builder-el-no-sibling enable_toggles\"><section class=\"av_toggle_section\"><div class=\"single_toggle\" data-tags=\"{Alle} \"><div id=\"toggle-id-3-container\" class=\"toggle_wrap active_tc\"><div class=\"toggle_content invers-color \"><p>Other reasons why the test may fail include the existence of an egg donation about which we were not informed, a &ldquo;vanishing twin&rdquo; situation, or previously unknown maternal chromosomal disorders.<\/p><p>If you need help interpreting the findings or have any questions on the methods used in the Harmony<sup>&reg;<\/sup>&nbsp;Test, you can consult our team of qualified physicians including specialists in human genetics, laboratory medicine and obstetrics\/gynaecology.<\/p><p>Free kits with the CE-labelled blood collection tubes for the blood samples and the transport material can be ordered in the following ways:<\/p><ul><li>using our&nbsp;<a title=\"Contact\" href=\"https:\/\/www.cenata.de\/en\/contact\/\">contact form<\/a><\/li><li>by fax: +49 7071 565 44 444<\/li><li>by phone +49 7071 565 44 430<\/li><\/ul><p>The order request form to be completed by the patient is included with the sampling kit and can also be downloaded from our homepage.<\/p><\/div><\/div><\/div><\/section><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e84be8 elementor-widget elementor-widget-text-editor\" data-id=\"1e84be8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464\" target=\"_blank\" rel=\"noopener\">Bevilacqua E, Gil MM, Nicolaides KH, Ordo&ntilde;ez E, Cirigliano V, Dierickx H, Willems PJ, Jani JC.&nbsp;<span lang=\"en-US\">Performance of screening for aneuploidies by cell-free DNA analysis of maternal blood in twin pregnancies.&nbsp;<\/span>Ultrasound Obstet Gynecol. 2015 Jan;45(1):61-6. doi: 10.1002\/uog.14690. Epub 2014 Dec 4.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-600-2\"><span lang=\"en-US\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24247435\" target=\"_blank\" rel=\"noopener\">del Mar Gil M, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free DNA analysis for trisomy risk assessment in first-trimester twin pregnancies. Fetal Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-2\">&#8617;<\/a><\/span><\/span><\/li><li id=\"fn-600-3\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23553731\" target=\"_blank\" rel=\"noopener\">Wang E1, Batey A, Struble C, Musci T, Song K, Oliphant A. Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma. Prenat Diagn. 2013 Jul;33(7):662-6. doi: 10.1002\/pd.4119. Epub 2013 May 9.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-3\">&#8617;<\/a><\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6aaf377 elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6aaf377\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8c161ff\" data-id=\"8c161ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-121e43e elementor-widget elementor-widget-heading\" data-id=\"121e43e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Harmony&reg; Test procedure<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5947838 elementor-widget elementor-widget-text-editor\" data-id=\"5947838\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><header class=\"entry-content-header\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed from week 10+0 of the pregnancy. Before carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, the patient should be given an ultrasound scan to determine the gestational age and to check whether it is a singleton or multiple pregnancy.<\/p><\/header><\/header><\/header><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-732d2a7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"732d2a7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8727335\" data-id=\"8727335\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-87ce46e elementor-widget elementor-widget-image\" data-id=\"87ce46e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"723\" height=\"1024\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg\" class=\"attachment-large size-large wp-image-21969\" alt=\"Test procedure\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-723x1024.jpg 723w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-212x300.jpg 212w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-768x1088.jpg 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1085x1536.jpg 1085w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN-1446x2048.jpg 1446w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/phys-procedure-EN.jpg 1557w\" sizes=\"(max-width: 723px) 100vw, 723px\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3c7ed4 elementor-widget elementor-widget-toggle\" data-id=\"a3c7ed4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1711\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1711\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Requirements for the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1711\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1711\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be performed with all singleton or twin pregnancies, irrespective of the manner of conception (including&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>). Data indicates that the detection rate for twin pregnancies (93%) is slightly lower than for singleton pregnancies.<sup class=\"footnote\"><a id=\"fnref-600-1\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-1\">1<\/a><\/sup>,<sup class=\"footnote\"><a id=\"fnref-600-2\" href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fn-600-2\">2<\/a><\/sup>&nbsp;It is not yet possible to test twin pregnancies for sex&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;anomalies (X, Y) such as Turner or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/klinefelter-syndrome\/\" target=\"_self\" title=\"This chromosomal disorder affects males and is characterised by an extra X-chromosome in all, or in a proportion, of the cells of the body. Further information about Klinefelter syndrome can be found here.\" class=\"encyclopedia\">Klinefelter syndrome<\/a>s and the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>.<\/p><p>The table below provides an overview of which Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible with different types of pregnancies.<br><br>\n<\/p><table id=\"tablepress-3-no-2\" class=\"tablepress tablepress-id-3\">\n<tbody>\n<tr class=\"row-1\">\n\t<td class=\"column-1\"><\/td><td class=\"column-2\">Singleton pregnancies incl. all IVF pregnancies<\/td><td class=\"column-3\">Twin pregnancies incl. all IVF pregnancies<\/td><td class=\"column-4\">More than two fetuses<\/td>\n<\/tr>\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Harmony&reg; Test<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Harmony&reg; with with X\/Y analysis<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\"><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a><\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">sex determination<\/td><td class=\"column-2\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/haken.png\" alt=\"Haken\" width=\"25\" height=\"27\" class=\"alignnone size-full wp-image-1356\"><\/td><td class=\"column-4\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/h_kreuz.png\" alt=\"h_kreuz\" width=\"19\" height=\"19\" class=\"alignnone size-full wp-image-1359\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<br><br><p>An important requirement for the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test is detailed, open and objective patient counseling in accordance with the German Genetic Diagnostics Act. If the patient decides to take the test, 2 x 9 ml of venous blood should be drawn into special blood tubes (provided). After the request form has been fully completed, the two blood tubes should be packed as described in the instructions (included in the sampling kit) and sent by post or courier.<\/p><p>The cell-free&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;remains stable for approximately 9 days in the special test tubes. Cenata will only accept samples that are not more than 7 days old. The samples should thus be sent as quickly as possible after the blood draw. The samples should stay at room temperature and never be cooled or frozen since haemolysis will occur, and the test cannot be analysed.<\/p><p>The test is evaluated using CE-certified software.<\/p><p>On average it takes 3 working days from its receipt to process the sample until the results are returned. This means that you will usually have the results for your patient on the 5th working day after the blood sample was taken.<\/p><p>If the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is to be determined during the test, the patient may only be informed of this after week 12+0 of the pregnancy in accordance with the Genetic Diagnostics Act (post-conception, corresponding to week 14 of the pregnancy when calculated starting after the last period). If the patient is not yet in week 14+0 of the pregnancy when the results are ready we will send you (the requesting physician) partial findings that do not contain information on the sex of the fetus. When week 14+0 of the pregnancy is reached we will automatically send you the report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1712\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1712\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Quality parameters of the Harmony&reg; Test<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1712\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1712\"><p>Each patient sample undergoes a multi-stage quality control process in our laboratory.<\/p><p>The first quality control takes place directly at the sample entrance. Here it is determined whether the durability, the duration of transport, the information on the request form as well as the quantity and consistency of the sample meet the specified quality requirements.<br>During processing in the laboratory, each analysis must pass a variety of quality control criteria. These are listed in the overview below:<\/p><table><tbody><tr><td width=\"149\"><strong>Parameter<\/strong><\/td><td width=\"465\"><strong>Description<\/strong><\/td><\/tr><tr><td width=\"149\"><strong>Array Quality<\/strong><\/td><td width=\"465\">General&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;quality<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction<\/strong><\/td><td width=\"465\">Amount of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> relative to maternal cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a><\/td><\/tr><tr><td width=\"149\"><strong>Signal<\/strong><\/td><td width=\"465\">Signal intensity of the measurement<\/td><\/tr><tr><td width=\"149\"><strong><a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> Quality<\/strong><\/td><td width=\"465\">Indication of the overall quality of the analysis. Indication of another <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> species in the sample.<\/td><\/tr><tr><td width=\"149\"><strong>Noise<\/strong><\/td><td width=\"465\">Intensity of the background signal<\/td><\/tr><tr><td width=\"149\"><strong>Signal to Noise<\/strong><\/td><td width=\"465\">Indication of the ratio of the signal intensity to the background signal<\/td><\/tr><\/tbody><\/table><p>Only when all parameters reach a minimum value, an analysis result is recieved, and the detailed report is created.<\/p><p>This is followed by the third stage of result release &ndash; medical validation. Each report is reviewed and approved by a team of qualified physicians and scientists.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1713\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1713\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Reasons for test failure<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1713\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1713\"><p>In a small number of cases, the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>) in the blood may be too low for results to be obtained. In these cases, Cenata will automatically repeat the test. If no clear results are obtained from the repeat test, the report will be returned as &ldquo;not analysable&rdquo; and Cenata will not charge the patient for the test. A new blood sample may be submitted at a slightly later date, as the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction) in the mother&rsquo;s blood increases with the length of the pregnancy.<\/p><figure id=\"attachment_21970\" aria-describedby=\"caption-attachment-21970\" style=\"width: 1432px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-21970 size-full\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg\" alt=\"\" width=\"1432\" height=\"809\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN.jpg 1432w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-300x169.jpg 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-1024x579.jpg 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/2016\/11\/SSW_cffDNA_EN-768x434.jpg 768w\" sizes=\"(max-width: 1432px) 100vw, 1432px\"><\/a><figcaption id=\"caption-attachment-21970\" class=\"wp-caption-text\">Relationship of the &ldquo;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Fraction&rdquo; and the week of pregnancy (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/ssw\/\" target=\"_self\" title='Schwangerschaftswoche (German for \"week of pregnancy\").' class=\"encyclopedia\">SSW<\/a>)<\/figcaption><\/figure><div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-7 el_after_av_one_half avia-builder-el-last column-top-margin\"><div class=\"togglecontainer toggle_close_all avia-builder-el-8 avia-builder-el-no-sibling enable_toggles\"><section class=\"av_toggle_section\"><div class=\"single_toggle\" data-tags=\"{Alle} \"><div id=\"toggle-id-3-container\" class=\"toggle_wrap active_tc\"><div class=\"toggle_content invers-color \"><p>Other reasons why the test may fail include the existence of an egg donation about which we were not informed, a &ldquo;vanishing twin&rdquo; situation, or previously unknown maternal chromosomal disorders.<\/p><p>If you need help interpreting the findings or have any questions on the methods used in the Harmony<sup>&reg;<\/sup>&nbsp;Test, you can consult our team of qualified physicians including specialists in human genetics, laboratory medicine and obstetrics\/gynaecology.<\/p><p>Free kits with the CE-labelled blood collection tubes for the blood samples and the transport material can be ordered in the following ways:<\/p><ul><li>using our&nbsp;<a title=\"Contact\" href=\"https:\/\/www.cenata.de\/en\/contact\/\">contact form<\/a><\/li><li>by fax: +49 7071 565 44 444<\/li><li>by phone +49 7071 565 44 430<\/li><\/ul><p>The order request form to be completed by the patient is included with the sampling kit and can also be downloaded from our homepage.<\/p><\/div><\/div><\/div><\/section><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a1a5a1 elementor-widget elementor-widget-text-editor\" data-id=\"2a1a5a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464\" target=\"_blank\" rel=\"noopener\">Bevilacqua E, Gil MM, Nicolaides KH, Ordo&ntilde;ez E, Cirigliano V, Dierickx H, Willems PJ, Jani JC.&nbsp;<span lang=\"en-US\">Performance of screening for aneuploidies by cell-free DNA analysis of maternal blood in twin pregnancies.&nbsp;<\/span>Ultrasound Obstet Gynecol. 2015 Jan;45(1):61-6. doi: 10.1002\/uog.14690. Epub 2014 Dec 4.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-600-2\"><span lang=\"en-US\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24247435\" target=\"_blank\" rel=\"noopener\">del Mar Gil M, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free DNA analysis for trisomy risk assessment in first-trimester twin pregnancies. Fetal Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-2\">&#8617;<\/a><\/span><\/span><\/li><li id=\"fn-600-3\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23553731\" target=\"_blank\" rel=\"noopener\">Wang E1, Batey A, Struble C, Musci T, Song K, Oliphant A. Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma. Prenat Diagn. 2013 Jul;33(7):662-6. doi: 10.1002\/pd.4119. Epub 2013 May 9.<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/#fnref-600-3\">&#8617;<\/a><\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Highest Standard.For your patients. Highest Standard.For your patients. Highest Standard.For your patients. FOR PHYSICIANS SEARCH Harmony\u00ae Test procedure The Harmony\u00ae\u00a0Test can be performed from week 10+0 of the pregnancy. Before carrying out a Harmony\u00ae\u00a0Test, the patient should be given an ultrasound scan to determine the gestational age and to check whether it is a singleton [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":594,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-600","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/comments?post=600"}],"version-history":[{"count":52,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/600\/revisions"}],"predecessor-version":[{"id":32942,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/600\/revisions\/32942"}],"up":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/594"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}