{"id":29298,"date":"2023-10-17T11:52:44","date_gmt":"2023-10-17T10:52:44","guid":{"rendered":"https:\/\/www.cenata.de\/?page_id=29298"},"modified":"2026-03-30T10:47:14","modified_gmt":"2026-03-30T09:47:14","slug":"di-george-syndrome-en","status":"publish","type":"page","link":"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/","title":{"rendered":"Di George syndrome en"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"29298\" class=\"elementor elementor-29298\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ffde03b elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ffde03b\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a18e074\" data-id=\"a18e074\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b1ec75d elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"b1ec75d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9fa21da elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9fa21da\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0adab08\" data-id=\"0adab08\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f30bcb3 elementor-hidden-mobile elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f30bcb3\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-896b033\" data-id=\"896b033\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63209b5 elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"63209b5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7148d83 elementor-hidden-mobile elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7148d83\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f5662d1\" data-id=\"f5662d1\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-07be468 elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"07be468\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-02a14d6\" data-id=\"02a14d6\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ecc021d elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"ecc021d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Highest Standard.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">For your patients.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-806210e elementor-hidden-tablet elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"806210e\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-809b523\" data-id=\"809b523\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f5f3e1d elementor-section-stretched elementor-hidden-mobile elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f5f3e1d\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6dc8d1c elementor-hidden-mobile\" data-id=\"6dc8d1c\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-93a0141 elementor-widget elementor-widget-heading\" data-id=\"93a0141\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR PHYSICIANS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff53660 elementor-nav-menu__align-end elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"ff53660\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Menu\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-ff53660\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-ff53660\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-25e5089 elementor-widget elementor-widget-heading\" data-id=\"25e5089\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7f7425 elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"f7f7425\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-f7f7425\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-f7f7425\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-2d00b9f\" data-id=\"2d00b9f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-67feef7 elementor-widget elementor-widget-heading\" data-id=\"67feef7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Microdeletion 22q11.2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88491a2 elementor-widget elementor-widget-text-editor\" data-id=\"88491a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><h4><strong>(DiGeorge syndrome)<\/strong><\/h4><p>Prenatal screening with the Harmony<sup>&reg;<\/sup>&nbsp;Test for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;is possible from gestational week 10+0.<\/p><p>The proprietary&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\">DANSR<\/a> assay (digital analysis of selected regions) of the Harmony<sup>&reg;<\/sup>&nbsp;Test is able to detect about 75% of all cases with a <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>, including those smaller than 3 Mb at a false-positive rate of 0.5%&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-3\"><sup>1<\/sup><\/a>.<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-29326\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1024x567.png\" alt=\"Chromosomale Region\" width=\"500\" height=\"277\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1024x567.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-300x166.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-768x425.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1536x850.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-2048x1133.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><\/header><p><img decoding=\"async\" class=\"aligncenter wp-image-29328\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png\" alt=\"Chromosome 22\" width=\"500\" height=\"300\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png 4524w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-300x180.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1024x614.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-768x461.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1536x921.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-2048x1229.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><p>Screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;by the Harmony<sup>&reg;<\/sup>&nbsp;Test determines the probability for the presence of this genetic disorder. However, the test is not able to ascertain the clinical severity of the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>In singleton pregnancies the analysis for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can be added to all other test options.<\/p><p>As each additional test increases the overall false-positive rate of a non-invasive prenatal test&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>2<\/sup><\/a>, we recommend requesting the test option only in pregnancies with an increased risk for this&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>As in screening for trisomies, screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can lead to false-positive results. Therefore, a report indicating a high risk for the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>&nbsp;has to be confirmed by an invasive diagnostic procedure (array-CGH), before further actions can be taken. The&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/positive-predictive-value-ppv\/\">positive predictive value (PPV)<\/a>&nbsp;is about 5%, depending on the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> in maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> fraction) <a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>3<\/sup><\/a>.<\/p><ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29131052\/\" target=\"_blank\" rel=\"noopener\">&nbsp;Schmid et al. Fetal Diagn Ther. 2018;44(4):299-304<\/a><\/li><li><a href=\"https:\/\/europepmc.org\/books\/n\/gene\/gr_22q11deletion\/?extid=20301354&amp;src=med\" target=\"_blank\" rel=\"noopener\">&nbsp;McDonald-McGinn et al. GeneReviews 1999 Sep 23<\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36738442\/\" target=\"_blank\" rel=\"noopener\">&nbsp;L&uuml;thgens K et al. Prenat Diagn. 2023 Mar;288-293<\/a><\/li><\/ol><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dd7c1a1 elementor-hidden-mobile elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dd7c1a1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-63d900a elementor-hidden-mobile\" data-id=\"63d900a\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4ff363a elementor-widget elementor-widget-heading\" data-id=\"4ff363a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR PHYSICIANS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe5397a elementor-nav-menu__align-end elementor-nav-menu--dropdown-mobile elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"fe5397a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Menu\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-fe5397a\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-fe5397a\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5540\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5541\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Aspects of counseling<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-5542\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/limitations-of-the-harmony-test\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Limitations of the Harmony&reg; Test<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-29425\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/di-george-syndrome-en\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Microdeletion 22q11.2<\/a><\/li>\n<li class=\"menu-item menu-item-type-taxonomy menu-item-object-tribe_events_cat menu-item-26479\"><a href=\"https:\/\/www.cenata.de\/en\/events\/category\/congresses\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Congresses<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23368\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/useful-links\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22963\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8974d07 elementor-widget elementor-widget-heading\" data-id=\"8974d07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf4fe17 elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"cf4fe17\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-cf4fe17\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-cf4fe17\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-cc97fa1\" data-id=\"cc97fa1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e990277 elementor-widget elementor-widget-heading\" data-id=\"e990277\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Microdeletion 22q11.2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d5cf01 elementor-widget elementor-widget-text-editor\" data-id=\"4d5cf01\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><h4><strong>(DiGeorge syndrome)<\/strong><\/h4><p>Prenatal screening with the Harmony<sup>&reg;<\/sup>&nbsp;Test for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;is possible from gestational week 10+0.<\/p><p>The proprietary&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\">DANSR<\/a> assay (digital analysis of selected regions) of the Harmony<sup>&reg;<\/sup>&nbsp;Test is able to detect about 75% of all cases with a <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>, including those smaller than 3 Mb at a false-positive rate of 0.5%&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-3\"><sup>1<\/sup><\/a>.<\/p><p><img decoding=\"async\" class=\"aligncenter wp-image-29326\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion.png\" alt=\"Chromosomale Region\" width=\"500\" height=\"277\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion.png 4553w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-300x166.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1024x567.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-768x425.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1536x850.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-2048x1133.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><\/header><p><img decoding=\"async\" class=\"aligncenter wp-image-29328\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png\" alt=\"Chromosome 22\" width=\"500\" height=\"300\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png 4524w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-300x180.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1024x614.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-768x461.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1536x921.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-2048x1229.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><p>Screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;by the Harmony<sup>&reg;<\/sup>&nbsp;Test determines the probability for the presence of this genetic disorder. However, the test is not able to ascertain the clinical severity of the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>In singleton pregnancies the analysis for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can be added to all other test options.<\/p><p>As each additional test increases the overall false-positive rate of a non-invasive prenatal test&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>2<\/sup><\/a>, we recommend requesting the test option only in pregnancies with an increased risk for this&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>As in screening for trisomies, screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can lead to false-positive results. Therefore, a report indicating a high risk for the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>&nbsp;has to be confirmed by an invasive diagnostic procedure (array-CGH), before further actions can be taken. The&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/positive-predictive-value-ppv\/\">positive predictive value (PPV)<\/a>&nbsp;is about 5%, depending on the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> in maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> fraction) <a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>3<\/sup><\/a>.<\/p><ol><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29131052\/\" target=\"_blank\" rel=\"noopener\">Schmid et al. Fetal Diagn Ther. 2018;44(4):299-304<\/a><\/li><li><a href=\"https:\/\/europepmc.org\/books\/n\/gene\/gr_22q11deletion\/?extid=20301354&amp;src=med\" target=\"_blank\" rel=\"noopener\">McDonald-McGinn et al. GeneReviews 1999 Sep 23<\/a><\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36738442\/\" target=\"_blank\" rel=\"noopener\">L&uuml;thgens K et al. Prenat Diagn. 2023 Mar;288-293<\/a><\/li><\/ol><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b20c9f3 elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b20c9f3\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-663b624\" data-id=\"663b624\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b426fb elementor-widget elementor-widget-heading\" data-id=\"0b426fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Microdeletion 22q11.2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d9f4a7 elementor-widget elementor-widget-text-editor\" data-id=\"0d9f4a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<header class=\"entry-content-header\"><header class=\"entry-content-header\"><h4><strong>(DiGeorge syndrome)<\/strong><\/h4><p>Prenatal screening with the Harmony<sup>&reg;<\/sup>&nbsp;Test for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;is possible from gestational week 10+0.<\/p><p>The proprietary&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\" target=\"_self\" title=\"&ldquo;Digital Analysis of Selected Regions: a computer-assisted analysis of specific pre-selected genetic regions. In the Harmony test, several hundred chromosome-specific genetic regions are tested for each chromosome of interest. These genetic regions have been previously defined in a complex procedure, allowing a stringent standardisation of the Harmony test. In previous methods (rMPS, random massively parallel&hellip;\" class=\"encyclopedia\">DANSR<\/a> assay (digital analysis of selected regions) of the Harmony<sup>&reg;<\/sup>&nbsp;Test is able to detect about 75% of all cases with a <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>, including those smaller than 3 Mb at a false-positive rate of 0.5%&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-3\"><sup>1<\/sup><\/a>.<\/p><p><img decoding=\"async\" class=\"aligncenter wp-image-29326\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion.png\" alt=\"Chromosomale Region\" width=\"500\" height=\"277\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion.png 4553w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-300x166.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1024x567.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-768x425.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-1536x850.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/22q11.2_chromosomaleRegion-2048x1133.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><\/header><p><img decoding=\"async\" class=\"aligncenter wp-image-29328\" src=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png\" alt=\"Chromosome 22\" width=\"500\" height=\"300\" srcset=\"https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung.png 4524w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-300x180.png 300w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1024x614.png 1024w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-768x461.png 768w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-1536x921.png 1536w, https:\/\/www.cenata.de\/wp-content\/uploads\/Chromosom22_MikrodeletionAbbildung-2048x1229.png 2048w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/p><p>Screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;by the Harmony<sup>&reg;<\/sup>&nbsp;Test determines the probability for the presence of this genetic disorder. However, the test is not able to ascertain the clinical severity of the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>In singleton pregnancies the analysis for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can be added to all other test options.<\/p><p>As each additional test increases the overall false-positive rate of a non-invasive prenatal test&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>2<\/sup><\/a>, we recommend requesting the test option only in pregnancies with an increased risk for this&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>.<\/p><p>As in screening for trisomies, screening for&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a> 22q11.2&nbsp;can lead to false-positive results. Therefore, a report indicating a high risk for the&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/\" target=\"_self\" title='A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a \"contiguous gene syndrome\", as several neighbouring genes are affected by the loss of&hellip;' class=\"encyclopedia\">microdeletion<\/a>&nbsp;has to be confirmed by an invasive diagnostic procedure (array-CGH), before further actions can be taken. The&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/positive-predictive-value-ppv\/\" target=\"_self\" title=\"The PPV reflects the rate of positive test results that are confirmed by chromosome analysis or after birth. The risk of the presence of a fetal trisomy 21 during pregnancy is approximately 1:500 for the average population. Almost all of these cases are correctly detected by the Harmony&reg; test (detection rate 99.3%[1.Stokowski R, Wang E,&hellip;\" class=\"encyclopedia\">positive predictive value (PPV)<\/a>&nbsp;is about 5%, depending on the amount of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cfdna\/\" target=\"_self\" title=\"cell free DNA: DNA fragments that naturally circulate freely in the bloodstream.\" class=\"encyclopedia\">cfDNA<\/a> in maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> fraction) <a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/aspects-of-counseling\/#fn-608-4\"><sup>3<\/sup><\/a>.<\/p><ol><li>[1] Schmid et al. <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Diagn Ther. 2018;44(4):299-304<\/li><li>&nbsp;McDonald-McGinn et al. GeneReviews 1999 Sep 23<\/li><li>&nbsp;L&uuml;thgens K et al. Prenat Diagn. 2023 Mar;288-293<\/li><\/ol><\/header>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Highest Standard.For your patients. Highest Standard.For your patients. Highest Standard.For your patients. FOR PHYSICIANS SEARCH Microdeletion 22q11.2 (DiGeorge syndrome) Prenatal screening with the Harmony\u00ae\u00a0Test for\u00a0microdeletion 22q11.2\u00a0is possible from gestational week 10+0. The proprietary\u00a0DANSR assay (digital analysis of selected regions) of the Harmony\u00ae\u00a0Test is able to detect about 75% of all cases with a microdeletion, including [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":594,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-29298","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/29298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/comments?post=29298"}],"version-history":[{"count":52,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/29298\/revisions"}],"predecessor-version":[{"id":33125,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/29298\/revisions\/33125"}],"up":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/594"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=29298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}