{"id":22918,"date":"2022-03-30T06:36:35","date_gmt":"2022-03-30T06:36:35","guid":{"rendered":"https:\/\/dev.cenata.de\/?page_id=22918"},"modified":"2025-11-18T08:29:36","modified_gmt":"2025-11-18T07:29:36","slug":"faq","status":"publish","type":"page","link":"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/","title":{"rendered":"Frequently Asked Questions"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"22918\" class=\"elementor elementor-22918\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d90fcef elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d90fcef\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e17e46a\" data-id=\"e17e46a\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-356dfc1 elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"356dfc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Reliable test.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Secure decision.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-59c7b2d elementor-hidden-mobile elementor-hidden-tablet elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"59c7b2d\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-58228c0\" data-id=\"58228c0\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ad06a8 elementor-hidden-mobile elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ad06a8\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ef6059e\" data-id=\"ef6059e\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a01957 elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"7a01957\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Reliable test.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Secure decision.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7ab47fb elementor-hidden-mobile elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ab47fb\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ff9b08b\" data-id=\"ff9b08b\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5abe519 elementor-hidden-tablet elementor-section-content-middle elementor-section-stretched elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5abe519\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"classic\",\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c0de3ae\" data-id=\"c0de3ae\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-824ad86 elementor--h-position-right elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"824ad86\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"autoplay_speed\":8000,\"transition\":\"fade\",\"navigation\":\"none\",\"autoplay\":\"yes\",\"pause_on_hover\":\"yes\",\"pause_on_interaction\":\"yes\",\"infinite\":\"yes\",\"transition_speed\":500}' data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slider\" dir=\"ltr\" data-animation=\"fadeInRight\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-3ab48d5 swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Reliable test.<\/div><\/div><\/div><\/div><div class=\"elementor-repeater-item-1edd39b swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\"><\/div><div class=\"swiper-slide-inner\"><div class=\"swiper-slide-contents\"><div class=\"elementor-slide-heading\">Secure decision.<\/div><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-28c0458 elementor-hidden-tablet elementor-section-content-middle elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"28c0458\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"background_background\":\"gradient\"}'>\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eb25a55\" data-id=\"eb25a55\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fa80e5a elementor-section-stretched elementor-hidden-mobile elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fa80e5a\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-90750e7 elementor-hidden-mobile\" data-id=\"90750e7\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-487ac84 elementor-widget elementor-widget-heading\" data-id=\"487ac84\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR EXPECTANT PARENTS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ccf2fa elementor-nav-menu__align-end elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"0ccf2fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Men&uuml;\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-0ccf2fa\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22939\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23371\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/understanding-the-results\/\" class=\"elementor-item menu-link\">Understanding the results<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23373\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-numerical-chromosomal-disorders\/\" class=\"elementor-item menu-link\">Information on numerical chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23372\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-x-and-y-chromosomal-disorders\/\" class=\"elementor-item menu-link\">Information on X and Y chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23375\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/reimbursement-of-costs\/\" class=\"elementor-item menu-link\">Reimbursement of costs<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22970\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/useful-links-for-parents\/\" class=\"elementor-item menu-link\">Useful links for parents<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22962\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22943\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/\" class=\"elementor-item menu-link\">Frequently Asked Questions<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-0ccf2fa\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22939\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23371\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/understanding-the-results\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Understanding the results<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23373\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-numerical-chromosomal-disorders\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Information on numerical chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23372\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-x-and-y-chromosomal-disorders\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Information on X and Y chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23375\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/reimbursement-of-costs\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Reimbursement of costs<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22970\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/useful-links-for-parents\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links for parents<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22962\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22943\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Frequently Asked Questions<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-69171e5 elementor-widget elementor-widget-heading\" data-id=\"69171e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0e7ff8 elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"a0e7ff8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-a0e7ff8\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-a0e7ff8\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-29ab9dc\" data-id=\"29ab9dc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d790c8b elementor-widget elementor-widget-heading\" data-id=\"d790c8b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">FAQ<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b882f8 elementor-widget elementor-widget-heading\" data-id=\"8b882f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">You can filter the FAQs here:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfe108 elementor-widget elementor-widget-text-editor\" data-id=\"bdfe108\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-1 el_after_av_layerslider avia-builder-el-no-sibling \"><div class=\"togglecontainer toggle_close_all avia-builder-el-4 el_after_av_textblock avia-builder-el-last enable_toggles\"><div class=\"taglist\"><a class=\"activeFilter\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{All}\">All<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Costs}\">Costs<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Dealing with the result}\">Dealing with the result<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Duration}\">Duration<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Overview Harmony&reg; Test}\">Overview Harmony&reg; Test<\/a><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b36da89 elementor-widget elementor-widget-toggle\" data-id=\"b36da89\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1881\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1881\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test constitute a risk for my unborn child?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1881\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1881\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a non-invasive prenatal test (<a class=\"encyclopedia\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>). The Harmony<sup>&reg;<\/sup>&nbsp;Test analyses&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;that can be found freely in the mother&rsquo;s blood. For this kind of&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;analysis, only a blood sample has to be taken from the mother, so there is absolutely no risk for your child.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1882\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1882\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Which chromosomal disorders can the Harmony&reg; Test detect?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1882\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1882\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test allows you to determine the risk of&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\">trisomy 21<\/a>&nbsp;(Down syndrome),&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\">trisomy 18<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\">trisomy 13<\/a>. Numerical anomalies of the sex <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s can also be identified.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1883\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1883\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How early can I perform the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1883\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1883\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be carried out on women who are in at least the 11th week of pregnancy (as of week 10+0). The Harmony<sup>&reg;<\/sup>&nbsp;Test analysis is based on the detection of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>,) in the mother&rsquo;s blood. Since the proportion of this <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> depends upon the week of pregnancy and must be over 4%, an earlier analysis is not possible.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1884\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1884\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test require anything more than just a blood sample?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1884\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1884\"><p>No, you only have to provide a blood sample in special test tubes for the Harmony<sup>&reg;<\/sup>&nbsp;Test. Prior to carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician should give you an ultrasound scan to determine the gestational age, and to determine if it is a singleton or multiple pregnancy. German law also requires that you receive comprehensive counseling before any genetic test is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1885\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1885\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How much will the Harmony&reg; Test cost?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1885\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1885\"><p>The cost of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends upon which chromosomal disorders are analysed. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1886\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-1886\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will I be charged any costs if the Harmony&reg; Test fails?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1886\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-1886\"><p>No. In a very small number of cases, it may not be possible to evaluate results of the Harmony<sup>&reg;<\/sup>&nbsp;Test. One common cause of this is that the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>) is too low in the mother&rsquo;s blood. There are other technical reasons why it may not be possible to evaluate the Harmony<sup>&reg;<\/sup>&nbsp;Test; in all of these cases, the test will be repeated automatically by Cenata. If no clear result is obtained with the second test, we notify your physician that the findings could not be analysed. In this case you will not be charged for the test by Cenata. You may wish to submit a new blood sample at a slightly later point in time since the content of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood increases with the length of pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1887\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-1887\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will the costs of the Harmony&reg; Test be reimbursed by my health insurance plan?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1887\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-1887\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a service that you have to pay for privately, as the costs are not currently reimbursed by public health insurance plans. Private health insurance plans normally cover these costs.We recommend that you check with your health insurance plan prior to having the test performed to see if they will cover the cost. The invoice you receive from Cenata shows the cost of the services rendered according to&nbsp;<a class=\"encyclopedia\" title='The \"Geb&uuml;hrenordnung f&uuml;r &Auml;rzte\" (GO&Auml;, statutory scale of fees for physicians) is responsible for regulating the prices of all medical services outside statutory health care in Germany. An invoice in accordance with the regulations of the GO&Auml; is sent to uninsured patients, patients in a private health insurance plans and patients who use individual health&hellip;' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/goae\/\" target=\"_self\">GO&Auml;<\/a>&nbsp;(statutory scale of fees for physicians). You can download forms and templates from our homepage that can be used to apply for a reimbursement of the costs by your health insurance plan. On the basis of this application, a number of public health insurance plans now reimburse the costs of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1888\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-1888\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test also be used to determine the sex of my child?  <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1888\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-1888\"><p>Sex determination is possible, irrespective of the method of conception (natural, by&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>, or by&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>). If you would like to know the probable sex of your child this must be indicated on the request form which you should complete together with your physician when he\/she takes your blood sample.<br>In accordance with the Genetic Diagnostics Act, we are only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings, without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1889\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-1889\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Do I have to pay extra to determine the sex of my unborn child with the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1889\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-1889\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test offers the opportunity of determining the sex of your unborn child. If you decide on the test option that analyses trisomies 21, 18, 13 but without an analysis of X\/Y chromosomal disorders, you can request sex determination as an extra service. Please ask your local provider about the prices. In accordance with the Genetic Diagnostics Act, your physician is only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18810\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-18810\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Tests if I am expecting twins?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18810\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-18810\"><p>Yes, the Harmony<sup>&reg;<\/sup>&nbsp;Test is also possible with twin pregnancies. You will learn whether one of your unborn children has&nbsp;<a class=\"encyclopedia\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\">trisomy<\/a>&nbsp;21, 18 or 13. The analysis of X- and Y-chromosomal anomalies is not possible for twin pregnancies at the present time.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18811\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-18811\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there additional costs in case of twin pregnancies?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18811\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-18811\"><p>No. The cost for the Harmony<sup>&reg;<\/sup>&nbsp;Test does not differ if you have a singleton or twin pregnancy. The price of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends on the test variant you choose. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18812\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-18812\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How does the determination of the fetal sex in twin pregnancies works?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18812\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-18812\"><p>The analysis of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is based on the detection of sequences of the Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, which is only available in male fetuses. If the Harmony<sup>&reg;<\/sup>&nbsp;Test detects a sequence of a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> it means that most probably at least one or even two of the fetuses are male. If the Harmony<sup>&reg;<\/sup>&nbsp;Test does not detect a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, it means that the twins are most likely female.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18813\" class=\"elementor-tab-title\" data-tab=\"13\" role=\"button\" aria-controls=\"elementor-tab-content-18813\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if my pregnancy is the result of IVF?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18813\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"13\" role=\"region\" aria-labelledby=\"elementor-tab-title-18813\"><p>Yes. You can use the Harmony<sup>&reg;<\/sup>&nbsp;Test even if your pregnancy is the result of an <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" class=\"encyclopedia\">in vitro fertilisation<\/a>. Please let us know if you had an egg donation or not. The Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result in case of a secret egg donation.<br>If you are expecting only one child, all three Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible. If you are expecting twins, only the Harmony<sup>&reg;<\/sup>&nbsp;Test option for trisomies 21, 18 and 13 + the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is possible at present.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18814\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-18814\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if I have received an egg donation?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18814\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-18814\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is still possible in the case of egg donation; it affects neither the detection rate nor the false positive rate. The laboratory, however, must be informed of the egg donation in order to perform the appropriate bioinformatic analyses. In case of a secret egg donation the Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result. If you have forgotten to note an egg donation when completing the request form, this can still be taken into account before the analysis is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18815\" class=\"elementor-tab-title\" data-tab=\"15\" role=\"button\" aria-controls=\"elementor-tab-content-18815\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">When will I receive the results of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18815\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"15\" role=\"region\" aria-labelledby=\"elementor-tab-title-18815\"><p>As a result of the unique design of the Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician will be sent the laboratory findings on average after 3 working days. This is possible because of the use of very reliable and accurate&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;technology, which replaces time-consuming sequencing. The time needed for this laboratory step can thus be reduced significantly. Your physician will receive the results by fax and will then discuss them with you.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18816\" class=\"elementor-tab-title\" data-tab=\"16\" role=\"button\" aria-controls=\"elementor-tab-content-18816\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How will I be informed of the result of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18816\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"16\" role=\"region\" aria-labelledby=\"elementor-tab-title-18816\"><p>In accordance with the German&nbsp;<a class=\"encyclopedia\" title=\"The Genetic Diagnosis Act has been in force in Germany since February 1, 2010. It regulates the procedures to be used for human genetic testing as well as the use of genetic material, data, and samples. The basic principles of the Act comprise the rights of the individual to informational self-determination. This includes both the&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/genetic-diagnosis-act\/\" target=\"_self\">Genetic Diagnosis Act<\/a>, the results of the Harmony<sup>&reg;<\/sup>&nbsp;Test will only be sent to the responsible physician of your choice. Your physician remains your main contact person before, during and after the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18817\" class=\"elementor-tab-title\" data-tab=\"17\" role=\"button\" aria-controls=\"elementor-tab-content-18817\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a positive result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18817\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"17\" role=\"region\" aria-labelledby=\"elementor-tab-title-18817\"><p>If the Harmony<sup>&reg;<\/sup>&nbsp;Test returns a positive result, there is a relatively high probability that your child has one of the tested chromosomal disorders. However, since the test can also produce a false positive result, a positive (ie. abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a class=\"encyclopedia\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\">chorionic villus sampling<\/a>&nbsp;or amniocentesis). Subsequent <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> analysis of those samples can then provide definitive diagnostic results. During genetic counseling, your physician will explain in detail the possible effects of the probable chromosomal disorder for your unborn child and provide you with information about further counseling options.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18818\" class=\"elementor-tab-title\" data-tab=\"18\" role=\"button\" aria-controls=\"elementor-tab-content-18818\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a negative result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18818\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"18\" role=\"region\" aria-labelledby=\"elementor-tab-title-18818\"><p>A negative Harmony<sup>&reg;<\/sup>&nbsp;Test result with no associated pathological ultrasound findings allows you to rule out the tested chromosomal disorders in your unborn child with a high degree of probability. The exception is <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>, which is detected in only approximately 85 &ndash; 90% of cases by non-invasive tests of maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a>), based upon the latest figures. However, this chromosomal disorder is very rare (with a frequency of 1:16000, depending on the mother&rsquo;s age) and can be easily detected by an ultrasound scan, e.g. during first&nbsp;<a class=\"encyclopedia\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\">trimester<\/a>&nbsp;screening. All <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods have limitations when it comes to the detection of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/structural-chromosomal-change\/\" target=\"_self\" title=\"A differentiation is made between structural and numerical chromosomal changes. Structural chromosomal changes are divided into two categories: balanced and unbalanced. Balanced chromosomal changes exist where part of a chromosome is relocated onto another. This shift in position does not normally affect the person with the change, but may affect their offspring. Unbalanced chromosomal disorders&hellip;\" class=\"encyclopedia\">structural chromosomal change<\/a>s. A negative test result therefore does not rule out the possibility of other disorders in your unborn child. A number of these disorders can be detected with an accurate ultrasound scan, for example, often from the 12th week of pregnancy. This is why a genetic test such as the Harmony<sup>&reg;<\/sup>&nbsp;Test can never replace a thorough ultrasound scan.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18819\" class=\"elementor-tab-title\" data-tab=\"19\" role=\"button\" aria-controls=\"elementor-tab-content-18819\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there other providers of NIPT?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18819\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"19\" role=\"region\" aria-labelledby=\"elementor-tab-title-18819\"><p>Yes, there are other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> providers in Germany. However, they either work with the&nbsp;<a class=\"encyclopedia\" title='rMPS = \"random massively parallel sequencing\": the parallel sequencing of randomly selected sequences of cell free maternal and fetal DNA. See also: MPSS.' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/rmps\/\" target=\"_self\">rMPS<\/a>&nbsp;method, which is based on a random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in the maternal blood, or by analysing single-nucleotide polymorphisms. The Harmony<sup>&reg;<\/sup>&nbsp;Test has a much greater sequencing depth through the specific sequencing of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s in question (<a class=\"encyclopedia\" title=\"&ldquo;Digital Analysis of Selected Regions: a computer-assisted analysis of specific pre-selected genetic regions. In the Harmony test, several hundred chromosome-specific genetic regions are tested for each chromosome of interest. These genetic regions have been previously defined in a complex procedure, allowing a stringent standardisation of the Harmony test. In previous methods (rMPS, random massively parallel&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\" target=\"_self\">DANSR<\/a>&nbsp;analysis). This means that is it less susceptible to interferences and more efficient since it concentrates on key sequences.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18820\" class=\"elementor-tab-title\" data-tab=\"20\" role=\"button\" aria-controls=\"elementor-tab-content-18820\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the result of the Harmony&reg; Test be affected by any medication that I take during pregnancy?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18820\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"20\" role=\"region\" aria-labelledby=\"elementor-tab-title-18820\"><p>It is known that treatment with heparin (low molecular weight heparin [LMWH] therapy) leads to a shift of the&nbsp;<a class=\"encyclopedia\" title=\"In molecular biology and genetics, the GC content refers to the proportion of the DNA bases guanine (G) and cytosine (C) that occur as pairs, relative to adenine (A) and thymine (T). The distribution of the GC base pairs differs between chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/gc-distribution\/\" target=\"_self\">GC distribution<\/a>&nbsp;of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood. In the Harmony<sup>&reg;<\/sup>&nbsp;Test, the distribution of GC content is pre-defined in the analysis method and the informative value is therefore not affected by a heparin therapy. Other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are based on the random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in maternal blood and are therefore less accurate during heparin therapy, resulting in increased test failures and a higher number of false positive and false negative results.<br>The Harmony<sup>&reg;<\/sup>&nbsp;Test is not affected by heparin treatment, and no other interactions between medications and <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are known to date.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18821\" class=\"elementor-tab-title\" data-tab=\"21\" role=\"button\" aria-controls=\"elementor-tab-content-18821\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why it may not be possible to evaluate the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18821\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"21\" role=\"region\" aria-labelledby=\"elementor-tab-title-18821\"><p>The Harmony<sup>&reg;<\/sup> Test analysis is based on the analysis of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>,) in the mother&rsquo;s blood. The proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> must be at least 4% for the test to be performed. This proportion is normally above 4% in week 10+0 of pregnancy. The weight of the pregnant woman also affects the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>. After a second blood sample at a later point in time during the pregnancy, the number of tests that cannot be analysed is significantely reduced.&nbsp;<br>Further reasons why the test may fail include an undisclosed egg donation, placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or previously unknown maternal chromosomal disorders. There will be no costs to you if no result can be obtained.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18822\" class=\"elementor-tab-title\" data-tab=\"22\" role=\"button\" aria-controls=\"elementor-tab-content-18822\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why the Harmony&reg; Test returns a false positive result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18822\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"22\" role=\"region\" aria-labelledby=\"elementor-tab-title-18822\"><p>Scientific studies show that the Harmony&reg; Test only returns a false-positive result in 0.04% of cases<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. False-negative results occur at an even lower percentage because of the excellent detection rates of the Harmony&reg; Test. The very rare false-positive\/false-negative results are usually due to a difference between the genetic type of the cells in the placenta and the genetic type of the child. Since the cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\">DNA<\/a>&nbsp;comes from the placenta, the Harmony&reg;&nbsp;Test basically reflects the genetic situation in the placenta. This means, for example, that some of the cells in the placenta display a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;and others do not (placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\">mosaic<\/a>). In these cases the Harmony&reg;&nbsp;Test may show a high risk for a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;even though the child has healthy&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>s.<\/p><p>Another possible cause of false positive or false negative results is the presence of a vanishing twin. For this reason, if a vanishing twin is suspected, we recommend performing the Harmony&reg; test no earlier than the 15th week of pregnancy, or at least eight weeks after the loss of the second fetus<sup class=\"footnote\">4<\/sup>.<\/p><p>Because of the possibility of false-positive results, a positive (abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\">chorionic villus sampling<\/a>&nbsp;or&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/amniotic-puncture\/\">amniotic puncture<\/a>) with subsequent&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>&nbsp;analysis before any further decisions can be made about the pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18823\" class=\"elementor-tab-title\" data-tab=\"23\" role=\"button\" aria-controls=\"elementor-tab-content-18823\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test return a false negative result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18823\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"23\" role=\"region\" aria-labelledby=\"elementor-tab-title-18823\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test has an excellent detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> of 99.3%. The detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" class=\"encyclopedia\">trisomy 18<\/a> is 97.4%. However, false negative results can also occur. This is particularly the case for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> (detection rate of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>: 93.8%)<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. However, <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> is detected relatively reliably in the ultrasound examination as part of the first <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> screening.<\/p><p>Twin pregnancies may also limit the detection rate. A study by Prof. Nicolaides in London showed a detection rate of approx. 93% for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> in twins<sup class=\"footnote\"><a id=\"fnref-680-3\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-3\">3<\/a><\/sup>.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-18824\" class=\"elementor-tab-title\" data-tab=\"24\" role=\"button\" aria-controls=\"elementor-tab-content-18824\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">I have submitted a sample for the Harmony&reg; Test but have now decided that I do not want to know the result. What should I do?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-18824\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"24\" role=\"region\" aria-labelledby=\"elementor-tab-title-18824\"><p>You should inform your physician directly of your decision. Since you have a right not to know in accordance with the German Genetic Diagnostics Act, the physician will then not inform you of the result of the Harmony<sup>&reg;<\/sup>&nbsp;Test. The Harmony<sup>&reg;<\/sup>&nbsp;Test can also be stopped at any time during the analysis. In this case, you will only be charged for the costs incurred up to the time at which the test is discontinued.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d79d787 elementor-widget elementor-widget-text-editor\" data-id=\"d79d787\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li id=\"fn-10-1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-2\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-2\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-3\">Gil MM, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> analysis for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" class=\"encyclopedia\">trisomy<\/a> risk assessment in first-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> twin pregnancies. <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15 (https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464)&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-3\">&#8617;<\/a><\/span><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f86cbc9 elementor-hidden-mobile elementor-hidden-desktop elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f86cbc9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0a62f9e elementor-hidden-mobile\" data-id=\"0a62f9e\" data-element_type=\"column\" data-e-type=\"column\" data-settings='{\"background_background\":\"classic\"}'>\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4501848 elementor-widget elementor-widget-heading\" data-id=\"4501848\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">FOR EXPECTANT PARENTS<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b2276bf elementor-nav-menu__align-end elementor-nav-menu--dropdown-mobile elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"b2276bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"layout\":\"vertical\",\"submenu_icon\":{\"value\":\"&lt;i class=\\\"\\\" aria-hidden=\\\"true\\\"&gt;&lt;\\\/i&gt;\",\"library\":\"\"},\"toggle\":\"burger\"}' data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<nav aria-label=\"Men&uuml;\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-b2276bf\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22939\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23371\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/understanding-the-results\/\" class=\"elementor-item menu-link\">Understanding the results<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23373\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-numerical-chromosomal-disorders\/\" class=\"elementor-item menu-link\">Information on numerical chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23372\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-x-and-y-chromosomal-disorders\/\" class=\"elementor-item menu-link\">Information on X and Y chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23375\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/reimbursement-of-costs\/\" class=\"elementor-item menu-link\">Reimbursement of costs<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22970\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/useful-links-for-parents\/\" class=\"elementor-item menu-link\">Useful links for parents<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22962\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\">Download<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22943\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/\" class=\"elementor-item menu-link\">Frequently Asked Questions<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t<div class=\"elementor-menu-toggle\" role=\"button\" tabindex=\"0\" aria-label=\"Menu Toggle\" aria-expanded=\"false\">\n\t\t\t<i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--open eicon-menu-bar\"><\/i><i aria-hidden=\"true\" role=\"presentation\" class=\"elementor-menu-toggle__icon--close eicon-close\"><\/i>\t\t<\/div>\n\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-b2276bf\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22939\"><a href=\"https:\/\/www.cenata.de\/en\/for-physicians\/harmony-test-procedure\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Harmony&reg; Test procedure<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23371\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/understanding-the-results\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Understanding the results<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23373\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-numerical-chromosomal-disorders\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Information on numerical chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23372\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/information-on-x-and-y-chromosomal-disorders\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Information on X and Y chromosomal disorders<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-23375\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/reimbursement-of-costs\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Reimbursement of costs<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22970\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/useful-links-for-parents\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Useful links for parents<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22962\"><a href=\"https:\/\/www.cenata.de\/en\/services\/download\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Download<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-22943\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/\" class=\"elementor-item menu-link\" tabindex=\"-1\">Frequently Asked Questions<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c344246 elementor-widget elementor-widget-heading\" data-id=\"c344246\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">SEARCH<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-178a76c elementor-search-form--skin-classic elementor-search-form--button-type-icon elementor-search-form--icon-search elementor-widget elementor-widget-search-form\" data-id=\"178a76c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings='{\"skin\":\"classic\"}' data-widget_type=\"search-form.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<search role=\"search\">\n\t\t\t<form class=\"elementor-search-form\" action=\"https:\/\/www.cenata.de\/en\/\" method=\"get\">\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-search-form__container\">\n\t\t\t\t\t<label class=\"elementor-screen-only\" for=\"elementor-search-form-178a76c\">Search<\/label>\n\n\t\t\t\t\t\n\t\t\t\t\t<input id=\"elementor-search-form-178a76c\" placeholder=\"Suche...\" class=\"elementor-search-form__input\" type=\"search\" name=\"s\" value=\"\">\n\t\t\t\t\t<input type=\"hidden\" name=\"lang\" value=\"en\">\n\t\t\t\t\t\t\t\t\t\t\t<button class=\"elementor-search-form__submit\" type=\"submit\" aria-label=\"Search\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-search\"><\/i>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t<\/search>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-062bcfc\" data-id=\"062bcfc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23f0650 elementor-widget elementor-widget-heading\" data-id=\"23f0650\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">FAQ<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a008b7 elementor-widget elementor-widget-heading\" data-id=\"9a008b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">You can filter the FAQs here:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-edd2f0a elementor-widget elementor-widget-text-editor\" data-id=\"edd2f0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-1 el_after_av_layerslider avia-builder-el-no-sibling \"><div class=\"togglecontainer toggle_close_all avia-builder-el-4 el_after_av_textblock avia-builder-el-last enable_toggles\"><div class=\"taglist\"><a class=\"activeFilter\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{All}\">All<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Costs}\">Costs<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Dealing with the result}\">Dealing with the result<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Duration}\">Duration<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Overview Harmony&reg; Test}\">Overview Harmony&reg; Test<\/a><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da91cfc elementor-widget elementor-widget-toggle\" data-id=\"da91cfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2291\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2291\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test constitute a risk for my unborn child?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2291\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2291\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a non-invasive prenatal test (<a class=\"encyclopedia\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>). The Harmony<sup>&reg;<\/sup>&nbsp;Test analyses&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;that can be found freely in the mother&rsquo;s blood. For this kind of&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;analysis, only a blood sample has to be taken from the mother, so there is absolutely no risk for your child.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2292\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2292\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Which Chromosomal disorders can the Harmony&reg; Test detect?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2292\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2292\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test allows you to determine the risk of&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\">trisomy 21<\/a>&nbsp;(Down syndrome),&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\">trisomy 18<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\">trisomy 13<\/a>. Numerical anomalies of the sex <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s can also be identified.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2293\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2293\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How early can I perform the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2293\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2293\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be carried out on women who are in at least the 11th week of pregnancy (as of week 10+0). The Harmony<sup>&reg;<\/sup>&nbsp;Test analysis is based on the detection of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>,) in the mother&rsquo;s blood. Since the proportion of this <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> depends upon the week of pregnancy and must be over 4%, an earlier analysis is not possible.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2294\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2294\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test require anything more than just a blood sample?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2294\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2294\"><p>No, you only have to provide a blood sample in special test tubes for the Harmony<sup>&reg;<\/sup>&nbsp;Test. Prior to carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician should give you an ultrasound scan to determine the gestational age, and to determine if it is a singleton or multiple pregnancy. German law also requires that you receive comprehensive counseling before any genetic test is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2295\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2295\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How much will the Harmony&reg; Test cost me?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2295\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2295\"><p>The cost of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends upon which chromosomal disorders are analysed. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2296\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-2296\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will I be charged any costs if the Harmony&reg; Test fails?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2296\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-2296\"><p>No. In a very small number of cases, it may not be possible to evaluate results of the Harmony<sup>&reg;<\/sup>&nbsp;Test. One common cause of this is that the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>) is too low in the mother&rsquo;s blood. There are other technical reasons why it may not be possible to evaluate the Harmony<sup>&reg;<\/sup>&nbsp;Test; in all of these cases, the test will be repeated automatically by Cenata. If no clear result is obtained with the second test, we notify your physician that the findings could not be analysed. In this case you will not be charged for the test by Cenata. You may wish to submit a new blood sample at a slightly later point in time since the content of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood increases with the length of pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2297\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-2297\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will the costs of the Harmony&reg; Test be reimbursed by my health insurance plan?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2297\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-2297\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a service that you have to pay for privately, as the costs are not currently reimbursed by public health insurance plans. Private health insurance plans normally cover these costs.We recommend that you check with your health insurance plan prior to having the test performed to see if they will cover the cost. The invoice you receive from Cenata shows the cost of the services rendered according to&nbsp;<a class=\"encyclopedia\" title='The \"Geb&uuml;hrenordnung f&uuml;r &Auml;rzte\" (GO&Auml;, statutory scale of fees for physicians) is responsible for regulating the prices of all medical services outside statutory health care in Germany. An invoice in accordance with the regulations of the GO&Auml; is sent to uninsured patients, patients in a private health insurance plans and patients who use individual health&hellip;' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/goae\/\" target=\"_self\">GO&Auml;<\/a>&nbsp;(statutory scale of fees for physicians). You can download forms and templates from our homepage that can be used to apply for a reimbursement of the costs by your health insurance plan. On the basis of this application, a number of public health insurance plans now reimburse the costs of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2298\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-2298\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test also be used to determine the sex of my child?  <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2298\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-2298\"><p>Sex determination is possible, irrespective of the method of conception (natural, by&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>, or by&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>). If you would like to know the probable sex of your child this must be indicated on the request form which you should complete together with your physician when he\/she takes your blood sample.<br>In accordance with the Genetic Diagnostics Act, we are only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings, without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2299\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-2299\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Do I have to pay extra to determine the sex of my unborn child with the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2299\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-2299\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test offers the opportunity of determining the sex of your unborn child. If you decide on the test option that analyses trisomies 21, 18, 13 but without an analysis of X\/Y chromosomal disorders, you can request sex determination as an extra service. Please ask your local provider about the prices. In accordance with the Genetic Diagnostics Act, your physician is only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22910\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-22910\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Tests if i am expecting twins?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22910\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-22910\"><p>Yes, the Harmony<sup>&reg;<\/sup>&nbsp;Test is also possible with twin pregnancies. You will learn whether one of your unborn children has&nbsp;<a class=\"encyclopedia\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\">trisomy<\/a>&nbsp;21, 18 or 13. The analysis of X- and Y-chromosomal anomalies is not possible for twin pregnancies at the present time.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22911\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-22911\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there additional costs in case of twin pregnancies?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22911\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-22911\"><p>No. The cost for the Harmony<sup>&reg;<\/sup>&nbsp;Test does not differ if you have a singleton or twin pregnancy. The price of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends on the test variant you choose. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22912\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-22912\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How does the determination of the fetal sex in twin pregnancies works?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22912\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-22912\"><p>The analysis of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is based on the detection of sequences of the Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, which is only available in male fetuses. If the Harmony<sup>&reg;<\/sup>&nbsp;Test detects a sequence of a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> it means that most probably at least one or even two of the fetuses are male. If the Harmony<sup>&reg;<\/sup>&nbsp;Test does not detect a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, it means that the twins are most likely female.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22913\" class=\"elementor-tab-title\" data-tab=\"13\" role=\"button\" aria-controls=\"elementor-tab-content-22913\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if my pregnancy is the result of IVF?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22913\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"13\" role=\"region\" aria-labelledby=\"elementor-tab-title-22913\"><p>Yes. You can use the Harmony<sup>&reg;<\/sup>&nbsp;Test even if your pregnancy is the result of an <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" class=\"encyclopedia\">in vitro fertilisation<\/a>. Please let us know if you had an egg donation or not. The Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result in case of a secret egg donation.<br>If you are expecting only one child, all three Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible. If you are expecting twins, only the Harmony<sup>&reg;<\/sup>&nbsp;Test option for trisomies 21, 18 and 13 + the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is possible at present.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22914\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-22914\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if i have received an egg donation?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22914\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-22914\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is still possible in the case of egg donation; it affects neither the detection rate nor the false positive rate. The laboratory, however, must be informed of the egg donation in order to perform the appropriate bioinformatic analyses. In case of a secret egg donation the Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result. If you have forgotten to note an egg donation when completing the request form, this can still be taken into account before the analysis is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22915\" class=\"elementor-tab-title\" data-tab=\"15\" role=\"button\" aria-controls=\"elementor-tab-content-22915\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">When will I receive the results of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22915\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"15\" role=\"region\" aria-labelledby=\"elementor-tab-title-22915\"><p>As a result of the unique design of the Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician will be sent the laboratory findings on average after 3 working days. This is possible because of the use of very reliable and accurate&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;technology, which replaces time-consuming sequencing. The time needed for this laboratory step can thus be reduced significantly. Your physician will receive the results by fax and will then discuss them with you.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22916\" class=\"elementor-tab-title\" data-tab=\"16\" role=\"button\" aria-controls=\"elementor-tab-content-22916\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How will I be informed of the result of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22916\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"16\" role=\"region\" aria-labelledby=\"elementor-tab-title-22916\"><p>In accordance with the German&nbsp;<a class=\"encyclopedia\" title=\"The Genetic Diagnosis Act has been in force in Germany since February 1, 2010. It regulates the procedures to be used for human genetic testing as well as the use of genetic material, data, and samples. The basic principles of the Act comprise the rights of the individual to informational self-determination. This includes both the&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/genetic-diagnosis-act\/\" target=\"_self\">Genetic Diagnosis Act<\/a>, the results of the Harmony<sup>&reg;<\/sup>&nbsp;Test will only be sent to the responsible physician of your choice. Your physician remains your main contact person before, during and after the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22917\" class=\"elementor-tab-title\" data-tab=\"17\" role=\"button\" aria-controls=\"elementor-tab-content-22917\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a positive result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22917\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"17\" role=\"region\" aria-labelledby=\"elementor-tab-title-22917\"><p>If the Harmony<sup>&reg;<\/sup>&nbsp;Test returns a positive result, there is a relatively high probability that your child has one of the tested chromosomal disorders. However, since the test can also produce a false positive result, a positive (ie. abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a class=\"encyclopedia\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\">chorionic villus sampling<\/a>&nbsp;or amniocentesis). Subsequent <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> analysis of those samples can then provide definitive diagnostic results. During genetic counseling, your physician will explain in detail the possible effects of the probable chromosomal disorder for your unborn child and provide you with information about further counseling options.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22918\" class=\"elementor-tab-title\" data-tab=\"18\" role=\"button\" aria-controls=\"elementor-tab-content-22918\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a negative result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22918\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"18\" role=\"region\" aria-labelledby=\"elementor-tab-title-22918\"><p>A negative Harmony<sup>&reg;<\/sup>&nbsp;Test result with no associated pathological ultrasound findings allows you to rule out the tested chromosomal disorders in your unborn child with a high degree of probability. The exception is <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>, which is detected in only approximately 85 &ndash; 90% of cases by non-invasive tests of maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a>), based upon the latest figures. However, this chromosomal disorder is very rare (with a frequency of 1:16000, depending on the mother&rsquo;s age) and can be easily detected by an ultrasound scan, e.g. during first&nbsp;<a class=\"encyclopedia\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\">trimester<\/a>&nbsp;screening. All <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods have limitations when it comes to the detection of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/structural-chromosomal-change\/\" target=\"_self\" title=\"A differentiation is made between structural and numerical chromosomal changes. Structural chromosomal changes are divided into two categories: balanced and unbalanced. Balanced chromosomal changes exist where part of a chromosome is relocated onto another. This shift in position does not normally affect the person with the change, but may affect their offspring. Unbalanced chromosomal disorders&hellip;\" class=\"encyclopedia\">structural chromosomal change<\/a>s. A negative test result therefore does not rule out the possibility of other disorders in your unborn child. A number of these disorders can be detected with an accurate ultrasound scan, for example, often from the 12th week of pregnancy. This is why a genetic test such as the Harmony<sup>&reg;<\/sup>&nbsp;Test can never replace a thorough ultrasound scan.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22919\" class=\"elementor-tab-title\" data-tab=\"19\" role=\"button\" aria-controls=\"elementor-tab-content-22919\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there other providers of NIPT?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22919\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"19\" role=\"region\" aria-labelledby=\"elementor-tab-title-22919\"><p>Yes, there are other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> providers in Germany. However, they either work with the&nbsp;<a class=\"encyclopedia\" title='rMPS = \"random massively parallel sequencing\": the parallel sequencing of randomly selected sequences of cell free maternal and fetal DNA. See also: MPSS.' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/rmps\/\" target=\"_self\">rMPS<\/a>&nbsp;method, which is based on a random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in the maternal blood, or by analysing single-nucleotide polymorphisms. The Harmony<sup>&reg;<\/sup>&nbsp;Test has a much greater sequencing depth through the specific sequencing of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s in question (<a class=\"encyclopedia\" title=\"&ldquo;Digital Analysis of Selected Regions: a computer-assisted analysis of specific pre-selected genetic regions. In the Harmony test, several hundred chromosome-specific genetic regions are tested for each chromosome of interest. These genetic regions have been previously defined in a complex procedure, allowing a stringent standardisation of the Harmony test. In previous methods (rMPS, random massively parallel&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\" target=\"_self\">DANSR<\/a>&nbsp;analysis). This means that is it less susceptible to interferences and more efficient since it concentrates on key sequences.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22920\" class=\"elementor-tab-title\" data-tab=\"20\" role=\"button\" aria-controls=\"elementor-tab-content-22920\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the result of the Harmony&reg; Test be affected by any medication that I take during pregnancy?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22920\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"20\" role=\"region\" aria-labelledby=\"elementor-tab-title-22920\"><p>It is known that treatment with heparin (low molecular weight heparin [LMWH] therapy) leads to a shift of the&nbsp;<a class=\"encyclopedia\" title=\"In molecular biology and genetics, the GC content refers to the proportion of the DNA bases guanine (G) and cytosine (C) that occur as pairs, relative to adenine (A) and thymine (T). The distribution of the GC base pairs differs between chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/gc-distribution\/\" target=\"_self\">GC distribution<\/a>&nbsp;of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood. In the Harmony<sup>&reg;<\/sup>&nbsp;Test, the distribution of GC content is pre-defined in the analysis method and the informative value is therefore not affected by a heparin therapy. Other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are based on the random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in maternal blood and are therefore less accurate during heparin therapy, resulting in increased test failures and a higher number of false positive and false negative results.<br>The Harmony<sup>&reg;<\/sup>&nbsp;Test is not affected by heparin treatment, and no other interactions between medications and <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are known to date.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22921\" class=\"elementor-tab-title\" data-tab=\"21\" role=\"button\" aria-controls=\"elementor-tab-content-22921\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why it may not be possible to evaluate the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22921\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"21\" role=\"region\" aria-labelledby=\"elementor-tab-title-22921\"><p>The Harmony<sup>&reg;<\/sup> Test analysis is based on the analysis of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>,) in the mother&rsquo;s blood. The proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> must be at least 4% for the test to be performed. This proportion is normally above 4% in week 10+0 of pregnancy. The weight of the pregnant woman also affects the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>. After a second blood sample at a later point in time during the pregnancy, the number of tests that cannot be analysed is significantely reduced.&nbsp;<br>Further reasons why the test may fail include an undisclosed egg donation, placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or previously unknown maternal chromosomal disorders. There will be no costs to you if no result can be obtained.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22922\" class=\"elementor-tab-title\" data-tab=\"22\" role=\"button\" aria-controls=\"elementor-tab-content-22922\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why the Harmony&reg; Test returns a false positive result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22922\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"22\" role=\"region\" aria-labelledby=\"elementor-tab-title-22922\"><p>Scientific studies show that the Harmony&reg; Test only returns a false-positive result in 0.04% of cases<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. False-negative results occur at an even lower percentage because of the excellent detection rates of the Harmony&reg; Test. The very rare false-positive\/false-negative results are usually due to a difference between the genetic type of the cells in the placenta and the genetic type of the child. Since the cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\">DNA<\/a>&nbsp;comes from the placenta, the Harmony&reg;&nbsp;Test basically reflects the genetic situation in the placenta. This means, for example, that some of the cells in the placenta display a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;and others do not (placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\">mosaic<\/a>). In these cases the Harmony&reg;&nbsp;Test may show a high risk for a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;even though the child has healthy&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>s.<\/p><p>Another possible cause of false positive or false negative results is the presence of a vanishing twin. For this reason, if a vanishing twin is suspected, we recommend performing the Harmony&reg; test no earlier than the 15th week of pregnancy, or at least eight weeks after the loss of the second fetus<sup class=\"footnote\">4<\/sup>.<\/p><p>Because of the possibility of false-positive results, a positive (abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\">chorionic villus sampling<\/a>&nbsp;or&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/amniotic-puncture\/\">amniotic puncture<\/a>) with subsequent&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>&nbsp;analysis before any further decisions can be made about the pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22923\" class=\"elementor-tab-title\" data-tab=\"23\" role=\"button\" aria-controls=\"elementor-tab-content-22923\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test return a false negative result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22923\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"23\" role=\"region\" aria-labelledby=\"elementor-tab-title-22923\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test has an excellent detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> of 99.3%. The detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" class=\"encyclopedia\">trisomy 18<\/a> is 97.4%. However, false negative results can also occur. This is particularly the case for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> (detection rate of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>: 93.8%)<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. However, <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> is detected relatively reliably in the ultrasound examination as part of the first <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> screening.<\/p><p>Twin pregnancies may also limit the detection rate. A study by Prof. Nicolaides in London showed a detection rate of approx. 93% for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> in twins<sup class=\"footnote\"><a id=\"fnref-680-3\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-3\">3<\/a><\/sup>.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-22924\" class=\"elementor-tab-title\" data-tab=\"24\" role=\"button\" aria-controls=\"elementor-tab-content-22924\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">I have submitted a sample for the Harmony&reg; Test but have now decided that I do not want to know the result. What should I do?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-22924\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"24\" role=\"region\" aria-labelledby=\"elementor-tab-title-22924\"><p>You should inform your physician directly of your decision. Since you have a right not to know in accordance with the German Genetic Diagnostics Act, the physician will then not inform you of the result of the Harmony<sup>&reg;<\/sup>&nbsp;Test. The Harmony<sup>&reg;<\/sup>&nbsp;Test can also be stopped at any time during the analysis. In this case, you will only be charged for the costs incurred up to the time at which the test is discontinued.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75767dd elementor-widget elementor-widget-text-editor\" data-id=\"75767dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li id=\"fn-10-1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-2\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-2\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-3\">Gil MM, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> analysis for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" class=\"encyclopedia\">trisomy<\/a> risk assessment in first-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> twin pregnancies. <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15 (https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464)&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-3\">&#8617;<\/a><\/span><\/li><li>van Eekhout JCA, Bax CJ, Schuurman LVP, Becking EC, van der Ven AJEM, Van Opstal D, Boon EMJ, Macville MVE, Bekker MN, Galjaard RJH; Dutch&nbsp;<a class=\"encyclopedia tooltipstered\" href=\"https:\/\/www.cenata.de\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>&nbsp;Consortium. Performance of non-invasive prenatal testing in vanishing-twin and multiple pregnancies: results of TRIDENT-2 study. Ultrasound Obstet Gynecol. 2025 Sep 6. doi: 10.1002\/uog.70015. Epub ahead of print. PMID: 40913805.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cd0fafe elementor-section-stretched elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cd0fafe\" data-element_type=\"section\" data-e-type=\"section\" data-settings='{\"stretch_section\":\"section-stretched\"}'>\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-68a75b7\" data-id=\"68a75b7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6977e2f elementor-widget elementor-widget-heading\" data-id=\"6977e2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">FAQ&#8203;<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ef48ef elementor-widget elementor-widget-heading\" data-id=\"7ef48ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">You can filter the FAQs here:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17eb700 elementor-widget elementor-widget-text-editor\" data-id=\"17eb700\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-1 el_after_av_layerslider avia-builder-el-no-sibling \"><div class=\"togglecontainer toggle_close_all avia-builder-el-4 el_after_av_textblock avia-builder-el-last enable_toggles\"><div class=\"taglist\"><div class=\"flex_column av_one_full flex_column_div av-zero-column-padding first avia-builder-el-1 el_after_av_layerslider avia-builder-el-no-sibling \"><div class=\"togglecontainer toggle_close_all avia-builder-el-4 el_after_av_textblock avia-builder-el-last enable_toggles\"><div class=\"taglist\"><a class=\"activeFilter\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{All}\">All<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Costs}\">Costs<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Dealing with the result}\">Dealing with the result<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Duration}\">Duration<\/a><span class=\"tag-seperator\">\/<\/span><a class=\"\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#\" data-tag=\"{Overview Harmony&reg; Test}\">Overview Harmony&reg; Test<\/a><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba4172a elementor-widget elementor-widget-toggle\" data-id=\"ba4172a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1951\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-1951\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test constitute a risk for my unborn child?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1951\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-1951\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a non-invasive prenatal test (<a class=\"encyclopedia\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>). The Harmony<sup>&reg;<\/sup>&nbsp;Test analyses&nbsp;<a class=\"encyclopedia\" title=\"Relating to the unborn child\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\">fetal<\/a>&nbsp;<a class=\"encyclopedia\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\">DNA<\/a>&nbsp;that can be found freely in the mother&rsquo;s blood. For this kind of&nbsp;<a class=\"encyclopedia\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\">chromosome<\/a>&nbsp;analysis, only a blood sample has to be taken from the mother, so there is absolutely no risk for your child.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1952\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-1952\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Which Chromosomal disorders can the Harmony&reg; Test detect?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1952\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-1952\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test allows you to determine the risk of&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\">trisomy 21<\/a>&nbsp;(Down syndrome),&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\">trisomy 18<\/a>&nbsp;and&nbsp;<a class=\"encyclopedia\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\">trisomy 13<\/a>. Numerical anomalies of the sex <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s can also be identified.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1953\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-1953\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How early can I perform the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1953\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-1953\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test can be carried out on women who are in at least the 11th week of pregnancy (as of week 10+0). The Harmony<sup>&reg;<\/sup>&nbsp;Test analysis is based on the detection of cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a class=\"encyclopedia\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\">cffDNA<\/a>,) in the mother&rsquo;s blood. Since the proportion of this <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> depends upon the week of pregnancy and must be over 4%, an earlier analysis is not possible.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1954\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-1954\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Does the Harmony&reg; Test require anything more than just a blood sample?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1954\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-1954\"><p>No, you only have to provide a blood sample in special test tubes for the Harmony<sup>&reg;<\/sup>&nbsp;Test. Prior to carrying out a Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician should give you an ultrasound scan to determine the gestational age, and to determine if it is a singleton or multiple pregnancy. German law also requires that you receive comprehensive counseling before any genetic test is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1955\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-1955\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How much will the Harmony&reg; Test cost me?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1955\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-1955\"><p>The cost of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends upon which chromosomal disorders are analysed. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1956\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-1956\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will I be charged any costs if the Harmony&reg; Test fails?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1956\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-1956\"><p>No. In a very small number of cases, it may not be possible to evaluate results of the Harmony<sup>&reg;<\/sup>&nbsp;Test. One common cause of this is that the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>) is too low in the mother&rsquo;s blood. There are other technical reasons why it may not be possible to evaluate the Harmony<sup>&reg;<\/sup>&nbsp;Test; in all of these cases, the test will be repeated automatically by Cenata. If no clear result is obtained with the second test, we notify your physician that the findings could not be analysed. In this case you will not be charged for the test by Cenata. You may wish to submit a new blood sample at a slightly later point in time since the content of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood increases with the length of pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1957\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-1957\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Will the costs of the Harmony&reg; Test be reimbursed by my health insurance plan?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1957\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-1957\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is a service that you have to pay for privately, as the costs are not currently reimbursed by public health insurance plans. Private health insurance plans normally cover these costs.We recommend that you check with your health insurance plan prior to having the test performed to see if they will cover the cost. The invoice you receive from Cenata shows the cost of the services rendered according to&nbsp;<a class=\"encyclopedia\" title='The \"Geb&uuml;hrenordnung f&uuml;r &Auml;rzte\" (GO&Auml;, statutory scale of fees for physicians) is responsible for regulating the prices of all medical services outside statutory health care in Germany. An invoice in accordance with the regulations of the GO&Auml; is sent to uninsured patients, patients in a private health insurance plans and patients who use individual health&hellip;' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/goae\/\" target=\"_self\">GO&Auml;<\/a>&nbsp;(statutory scale of fees for physicians). You can download forms and templates from our homepage that can be used to apply for a reimbursement of the costs by your health insurance plan. On the basis of this application, a number of public health insurance plans now reimburse the costs of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1958\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-1958\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test also be used to determine the sex of my child?  <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1958\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-1958\"><p>Sex determination is possible, irrespective of the method of conception (natural, by&nbsp;<a class=\"encyclopedia\" title=\"A method used in reproductive medicine in which an egg is harvested from a woman, fertilised outside of the body, and then implanted into a recipient woman who will carry the pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/egg-donation\/\" target=\"_self\">egg donation<\/a>, or by&nbsp;<a class=\"encyclopedia\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\">in vitro fertilisation<\/a>). If you would like to know the probable sex of your child this must be indicated on the request form which you should complete together with your physician when he\/she takes your blood sample.<br>In accordance with the Genetic Diagnostics Act, we are only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings, without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-1959\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-1959\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Do I have to pay extra to determine the sex of my unborn child with the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-1959\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-1959\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test offers the opportunity of determining the sex of your unborn child. If you decide on the test option that analyses trisomies 21, 18, 13 but without an analysis of X\/Y chromosomal disorders, you can request sex determination as an extra service. Please ask your local provider about the prices. In accordance with the Genetic Diagnostics Act, your physician is only allowed to inform you of the sex of your child when you reach week 14+0 of your pregnancy. If you wish to be informed of the sex and have not yet reached the 14th week of your pregnancy, we will initially only send your physician partial findings without the sex of your child. When week 14+0 of the pregnancy is reached we will automatically send your physician a report on the sex of the fetus.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19510\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-19510\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Tests if I am expecting twins?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19510\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-19510\"><p>Yes, the Harmony<sup>&reg;<\/sup>&nbsp;Test is also possible with twin pregnancies. You will learn whether one of your unborn children has&nbsp;<a class=\"encyclopedia\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\">trisomy<\/a>&nbsp;21, 18 or 13. The analysis of X- and Y-chromosomal anomalies is not possible for twin pregnancies at the present time.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19511\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-19511\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there additional costs in case of twin pregnancies?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19511\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-19511\"><p>No. The cost for the Harmony<sup>&reg;<\/sup>&nbsp;Test does not differ if you have a singleton or twin pregnancy. The price of the Harmony<sup>&reg;<\/sup>&nbsp;Test depends on the test variant you choose. Please ask your local distributor for the actual Harmony<sup>&reg;<\/sup>&nbsp;Test price.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19512\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-19512\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How does the determination of the fetal sex in twin pregnancies works?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19512\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-19512\"><p>The analysis of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is based on the detection of sequences of the Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, which is only available in male fetuses. If the Harmony<sup>&reg;<\/sup>&nbsp;Test detects a sequence of a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> it means that most probably at least one or even two of the fetuses are male. If the Harmony<sup>&reg;<\/sup>&nbsp;Test does not detect a Y-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>, it means that the twins are most likely female.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19513\" class=\"elementor-tab-title\" data-tab=\"13\" role=\"button\" aria-controls=\"elementor-tab-content-19513\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if my pregnancy is the result of IVF?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19513\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"13\" role=\"region\" aria-labelledby=\"elementor-tab-title-19513\"><p>Yes. You can use the Harmony<sup>&reg;<\/sup>&nbsp;Test even if your pregnancy is the result of an <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/in-vitro-fertilisation\/\" target=\"_self\" title=\"In vitro fertilisation (IVF) is a method of artificial insemination in which the actual fertilisation takes place outside of the body. The fertilised egg is then implanted into a woman's uterus for a normal pregnancy.\" class=\"encyclopedia\">in vitro fertilisation<\/a>. Please let us know if you had an egg donation or not. The Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result in case of a secret egg donation.<br>If you are expecting only one child, all three Harmony<sup>&reg;<\/sup>&nbsp;Test options are possible. If you are expecting twins, only the Harmony<sup>&reg;<\/sup>&nbsp;Test option for trisomies 21, 18 and 13 + the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> sex is possible at present.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19514\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-19514\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can I have the Harmony&reg; Test if I have received an egg donation?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19514\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-19514\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test is still possible in the case of egg donation; it affects neither the detection rate nor the false positive rate. The laboratory, however, must be informed of the egg donation in order to perform the appropriate bioinformatic analyses. In case of a secret egg donation the Harmony<sup>&reg;<\/sup>&nbsp;Test can not determine a result. If you have forgotten to note an egg donation when completing the request form, this can still be taken into account before the analysis is performed.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19515\" class=\"elementor-tab-title\" data-tab=\"15\" role=\"button\" aria-controls=\"elementor-tab-content-19515\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">When will I receive the results of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19515\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"15\" role=\"region\" aria-labelledby=\"elementor-tab-title-19515\"><p>As a result of the unique design of the Harmony<sup>&reg;<\/sup>&nbsp;Test, your physician will be sent the laboratory findings on average after 3 working days. This is possible because of the use of very reliable and accurate&nbsp;<a class=\"encyclopedia\" title=\"Technology that can use very small amounts of starting material (DNA or RNA) to analyse the expression of thousands of genes simultaneously.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/microarray\/\" target=\"_self\">microarray<\/a>&nbsp;technology, which replaces time-consuming sequencing. The time needed for this laboratory step can thus be reduced significantly. Your physician will receive the results by fax and will then discuss them with you.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19516\" class=\"elementor-tab-title\" data-tab=\"16\" role=\"button\" aria-controls=\"elementor-tab-content-19516\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">How will I be informed of the result of the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19516\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"16\" role=\"region\" aria-labelledby=\"elementor-tab-title-19516\"><p>In accordance with the German&nbsp;<a class=\"encyclopedia\" title=\"The Genetic Diagnosis Act has been in force in Germany since February 1, 2010. It regulates the procedures to be used for human genetic testing as well as the use of genetic material, data, and samples. The basic principles of the Act comprise the rights of the individual to informational self-determination. This includes both the&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/genetic-diagnosis-act\/\" target=\"_self\">Genetic Diagnosis Act<\/a>, the results of the Harmony<sup>&reg;<\/sup>&nbsp;Test will only be sent to the responsible physician of your choice. Your physician remains your main contact person before, during and after the performance of the Harmony<sup>&reg;<\/sup>&nbsp;Test.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19517\" class=\"elementor-tab-title\" data-tab=\"17\" role=\"button\" aria-controls=\"elementor-tab-content-19517\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a positive result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19517\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"17\" role=\"region\" aria-labelledby=\"elementor-tab-title-19517\"><p>If the Harmony<sup>&reg;<\/sup>&nbsp;Test returns a positive result, there is a relatively high probability that your child has one of the tested chromosomal disorders. However, since the test can also produce a false positive result, a positive (ie. abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a class=\"encyclopedia\" title=\"Invasive collection of placental cells through the cervix or abdominal wall to detect chromosomal diseases for prenatal diagnostics.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\" target=\"_self\">chorionic villus sampling<\/a>&nbsp;or amniocentesis). Subsequent <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a> analysis of those samples can then provide definitive diagnostic results. During genetic counseling, your physician will explain in detail the possible effects of the probable chromosomal disorder for your unborn child and provide you with information about further counseling options.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19518\" class=\"elementor-tab-title\" data-tab=\"18\" role=\"button\" aria-controls=\"elementor-tab-content-19518\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What does a negative result mean?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19518\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"18\" role=\"region\" aria-labelledby=\"elementor-tab-title-19518\"><p>A negative Harmony<sup>&reg;<\/sup>&nbsp;Test result with no associated pathological ultrasound findings allows you to rule out the tested chromosomal disorders in your unborn child with a high degree of probability. The exception is <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>, which is detected in only approximately 85 &ndash; 90% of cases by non-invasive tests of maternal blood (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a>), based upon the latest figures. However, this chromosomal disorder is very rare (with a frequency of 1:16000, depending on the mother&rsquo;s age) and can be easily detected by an ultrasound scan, e.g. during first&nbsp;<a class=\"encyclopedia\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\">trimester<\/a>&nbsp;screening. All <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods have limitations when it comes to the detection of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/structural-chromosomal-change\/\" target=\"_self\" title=\"A differentiation is made between structural and numerical chromosomal changes. Structural chromosomal changes are divided into two categories: balanced and unbalanced. Balanced chromosomal changes exist where part of a chromosome is relocated onto another. This shift in position does not normally affect the person with the change, but may affect their offspring. Unbalanced chromosomal disorders&hellip;\" class=\"encyclopedia\">structural chromosomal change<\/a>s. A negative test result therefore does not rule out the possibility of other disorders in your unborn child. A number of these disorders can be detected with an accurate ultrasound scan, for example, often from the 12th week of pregnancy. This is why a genetic test such as the Harmony<sup>&reg;<\/sup>&nbsp;Test can never replace a thorough ultrasound scan.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19519\" class=\"elementor-tab-title\" data-tab=\"19\" role=\"button\" aria-controls=\"elementor-tab-content-19519\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Are there other providers of NIPT?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19519\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"19\" role=\"region\" aria-labelledby=\"elementor-tab-title-19519\"><p>Yes, there are other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> providers in Germany. However, they either work with the&nbsp;<a class=\"encyclopedia\" title='rMPS = \"random massively parallel sequencing\": the parallel sequencing of randomly selected sequences of cell free maternal and fetal DNA. See also: MPSS.' href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/rmps\/\" target=\"_self\">rMPS<\/a>&nbsp;method, which is based on a random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in the maternal blood, or by analysing single-nucleotide polymorphisms. The Harmony<sup>&reg;<\/sup>&nbsp;Test has a much greater sequencing depth through the specific sequencing of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\" target=\"_self\" title=\"A chromosome is an complex of tightly-coiled DNA and the proteins which hold the structure together. Normal human cells contain 23 pairs of chromosomes - 22 autosomes and the X and Y sex chromosomes.\" class=\"encyclopedia\">chromosome<\/a>s in question (<a class=\"encyclopedia\" title=\"&ldquo;Digital Analysis of Selected Regions: a computer-assisted analysis of specific pre-selected genetic regions. In the Harmony test, several hundred chromosome-specific genetic regions are tested for each chromosome of interest. These genetic regions have been previously defined in a complex procedure, allowing a stringent standardisation of the Harmony test. In previous methods (rMPS, random massively parallel&hellip;\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dansr\/\" target=\"_self\">DANSR<\/a>&nbsp;analysis). This means that is it less susceptible to interferences and more efficient since it concentrates on key sequences.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19520\" class=\"elementor-tab-title\" data-tab=\"20\" role=\"button\" aria-controls=\"elementor-tab-content-19520\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the result of the Harmony&reg; Test be affected by any medication that I take during pregnancy?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19520\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"20\" role=\"region\" aria-labelledby=\"elementor-tab-title-19520\"><p>It is known that treatment with heparin (low molecular weight heparin [LMWH] therapy) leads to a shift of the&nbsp;<a class=\"encyclopedia\" title=\"In molecular biology and genetics, the GC content refers to the proportion of the DNA bases guanine (G) and cytosine (C) that occur as pairs, relative to adenine (A) and thymine (T). The distribution of the GC base pairs differs between chromosomes.\" href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/gc-distribution\/\" target=\"_self\">GC distribution<\/a>&nbsp;of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> in the mother&rsquo;s blood. In the Harmony<sup>&reg;<\/sup>&nbsp;Test, the distribution of GC content is pre-defined in the analysis method and the informative value is therefore not affected by a heparin therapy. Other <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are based on the random sequencing of all free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> fractions in maternal blood and are therefore less accurate during heparin therapy, resulting in increased test failures and a higher number of false positive and false negative results.<br>The Harmony<sup>&reg;<\/sup>&nbsp;Test is not affected by heparin treatment, and no other interactions between medications and <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/nipt\/\" target=\"_self\" title=\"Non-invasive prenatal tests are molecular genetic analyses in prenatal diagnostics to detect fetal chromosomal anomalies from the maternal blood, avoiding the risk of miscarriage inherent in more invasive methods.\" class=\"encyclopedia\">NIPT<\/a> methods are known to date.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19521\" class=\"elementor-tab-title\" data-tab=\"21\" role=\"button\" aria-controls=\"elementor-tab-content-19521\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why it may not be possible to evaluate the Harmony&reg; Test?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19521\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"21\" role=\"region\" aria-labelledby=\"elementor-tab-title-19521\"><p>The Harmony<sup>&reg;<\/sup> Test analysis is based on the analysis of free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">fetal<\/a> <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>,) in the mother&rsquo;s blood. The proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a> must be at least 4% for the test to be performed. This proportion is normally above 4% in week 10+0 of pregnancy. The weight of the pregnant woman also affects the proportion of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/cffdna\/\" target=\"_self\" title=\"cell free fetal DNA: during pregnancy, the mother's blood contains not only maternal DNA but also cell-free fetal DNA\" class=\"encyclopedia\">cffDNA<\/a>. After a second blood sample at a later point in time during the pregnancy, the number of tests that cannot be analysed is significantely reduced.&nbsp;<br>Further reasons why the test may fail include an undisclosed egg donation, placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\" target=\"_self\" title=\"In genetics the term mosaic describes an individual whose cells have different genotypes, but originates from a single fertilised ovum.\" class=\"encyclopedia\">mosaic<\/a>s or previously unknown maternal chromosomal disorders. There will be no costs to you if no result can be obtained.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19522\" class=\"elementor-tab-title\" data-tab=\"22\" role=\"button\" aria-controls=\"elementor-tab-content-19522\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">What are the reasons why the Harmony&reg; Test returns a false positive result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19522\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"22\" role=\"region\" aria-labelledby=\"elementor-tab-title-19522\"><p>Scientific studies show that the Harmony&reg; Test only returns a false-positive result in 0.04% of cases<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. False-negative results occur at an even lower percentage because of the excellent detection rates of the Harmony&reg; Test. The very rare false-positive\/false-negative results are usually due to a difference between the genetic type of the cells in the placenta and the genetic type of the child. Since the cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\">fetal<\/a>&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\">DNA<\/a>&nbsp;comes from the placenta, the Harmony&reg;&nbsp;Test basically reflects the genetic situation in the placenta. This means, for example, that some of the cells in the placenta display a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;and others do not (placental <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/mosaic\/\">mosaic<\/a>). In these cases the Harmony&reg;&nbsp;Test may show a high risk for a&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\">trisomy<\/a>&nbsp;even though the child has healthy&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>s.<\/p><p>Another possible cause of false positive or false negative results is the presence of a vanishing twin. For this reason, if a vanishing twin is suspected, we recommend performing the Harmony&reg; test no earlier than the 15th week of pregnancy, or at least eight weeks after the loss of the second fetus<sup class=\"footnote\">4<\/sup>.<\/p><p>Because of the possibility of false-positive results, a positive (abnormal) finding must always be confirmed by a second diagnostic, invasive method (<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chorionic-villus-sampling\/\">chorionic villus sampling<\/a>&nbsp;or&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/amniotic-puncture\/\">amniotic puncture<\/a>) with subsequent&nbsp;<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/chromosome\/\">chromosome<\/a>&nbsp;analysis before any further decisions can be made about the pregnancy.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19523\" class=\"elementor-tab-title\" data-tab=\"23\" role=\"button\" aria-controls=\"elementor-tab-content-19523\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Can the Harmony&reg; Test return a false negative result?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19523\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"23\" role=\"region\" aria-labelledby=\"elementor-tab-title-19523\"><p>The Harmony<sup>&reg;<\/sup>&nbsp;Test has an excellent detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> of 99.3%. The detection rate for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-18\/\" target=\"_self\" title=\"Trisomy 18 occurs when there are three copies of chromosome 18. Trisomy 18 is also called Edwards syndrome.\" class=\"encyclopedia\">trisomy 18<\/a> is 97.4%. However, false negative results can also occur. This is particularly the case for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> (detection rate of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a>: 93.8%)<sup class=\"footnote\"><a id=\"fnref-680-1\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-1\">1<\/a><\/sup>. However, <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-13\/\" target=\"_self\" title=\"Trisomy 13 occurs when there are three copies of chromosome 13. This leads to the development of Patau syndrome.\" class=\"encyclopedia\">trisomy 13<\/a> is detected relatively reliably in the ultrasound examination as part of the first <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> screening.<\/p><p>Twin pregnancies may also limit the detection rate. A study by Prof. Nicolaides in London showed a detection rate of approx. 93% for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy-21\/\" target=\"_self\" title=\"Trisomy 21 is the most common numerical chromosomal disorder in newborns. There are three copies of chromosome 21 and this leads to the development of Down syndrome.\" class=\"encyclopedia\">trisomy 21<\/a> in twins<sup class=\"footnote\"><a id=\"fnref-680-3\" href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fn-680-3\">3<\/a><\/sup>.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-19524\" class=\"elementor-tab-title\" data-tab=\"24\" role=\"button\" aria-controls=\"elementor-tab-content-19524\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-left\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-plus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-minus-square\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">I have submitted a sample for the Harmony&reg; Test but have now decided that I do not want to know the result. What should I do?<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-19524\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"24\" role=\"region\" aria-labelledby=\"elementor-tab-title-19524\"><p>You should inform your physician directly of your decision. Since you have a right not to know in accordance with the German Genetic Diagnostics Act, the physician will then not inform you of the result of the Harmony<sup>&reg;<\/sup>&nbsp;Test. The Harmony<sup>&reg;<\/sup>&nbsp;Test can also be stopped at any time during the analysis. In this case, you will only be charged for the costs incurred up to the time at which the test is discontinued.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c04518 elementor-widget elementor-widget-text-editor\" data-id=\"3c04518\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li id=\"fn-10-1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-1\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-2\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332378\" target=\"_blank\" rel=\"noopener\">Stokowski R, Wang E, White K, Batey A, Jacobsson B, Brar H, Balanarasimha M, Hollemon D, Sparks A, Nicolaides K, Musci TJ.: Clinical performance of non-invasive prenatal testing (NIPT) using targeted cell-free DNA analysis in maternal plasma with microarrays or next generation sequencing (NGS) is consistent across multiple controlled clinical studies. Prenat Diagn. 2015 Sep 1<\/a>&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-2\">&#8617;<\/a><\/span><\/li><li id=\"fn-680-3\">Gil MM, Quezada MS, Bregant B, Syngelaki A, Nicolaides KH. Cell-free <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> analysis for <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trisomy\/\" target=\"_self\" title=\"Trisomy means that there are three copies (trisom) of a complete or partial chromosome, instead of the normal two (disom).\" class=\"encyclopedia\">trisomy<\/a> risk assessment in first-<a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/trimester\/\" target=\"_self\" title=\"Trimester is the medical term used to describe the division of a pregnancy into three phases of three months each.\" class=\"encyclopedia\">trimester<\/a> twin pregnancies. <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/fetal\/\" target=\"_self\" title=\"Relating to the unborn child\" class=\"encyclopedia\">Fetal<\/a> Diagn Ther. 2014;35(3):204-11. doi: 10.1159\/000356495. Epub 2013 Nov 15 (https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25297464)&nbsp;<span class=\"footnotereverse\"><a href=\"https:\/\/www.cenata.de\/en\/for-expectant-parents\/faq\/#fnref-680-3\">&#8617;<\/a><\/span><\/li><li>van Eekhout JCA, Bax CJ, Schuurman LVP, Becking EC, van der Ven AJEM, Van Opstal D, Boon EMJ, Macville MVE, Bekker MN, Galjaard RJH; Dutch&nbsp;<a class=\"encyclopedia tooltipstered\" href=\"https:\/\/www.cenata.de\/encyclopedia\/nipt\/\" target=\"_self\">NIPT<\/a>&nbsp;Consortium. Performance of non-invasive prenatal testing in vanishing-twin and multiple pregnancies: results of TRIDENT-2 study. Ultrasound Obstet Gynecol. 2025 Sep 6. doi: 10.1002\/uog.70015. Epub ahead of print. PMID: 40913805.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Reliable test.Secure decision. Reliable test.Secure decision. Reliable test.Secure decision. FOR EXPECTANT PARENTS SEARCH FAQ You can filter the FAQs here: All\/Costs\/Dealing with the result\/Duration\/Overview Harmony\u00ae Test Does the Harmony\u00ae Test constitute a risk for my unborn child? The Harmony\u00ae\u00a0Test is a non-invasive prenatal test (NIPT). The Harmony\u00ae\u00a0Test analyses\u00a0fetal\u00a0DNA\u00a0that can be found freely in the mother\u2019s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":641,"menu_order":10,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-22918","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/22918","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/comments?post=22918"}],"version-history":[{"count":113,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/22918\/revisions"}],"predecessor-version":[{"id":32457,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/22918\/revisions\/32457"}],"up":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/pages\/641"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=22918"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}