{"id":23354,"date":"2018-07-02T10:27:18","date_gmt":"2018-07-02T09:27:18","guid":{"rendered":"https:\/\/dev.cenata.de\/encyclopedia\/microdeletion\/"},"modified":"2018-07-02T10:27:18","modified_gmt":"2018-07-02T09:27:18","slug":"microdeletion","status":"publish","type":"encyclopedia","link":"https:\/\/www.cenata.de\/en\/encyclopedia\/microdeletion\/","title":{"rendered":"Microdeletion"},"content":{"rendered":"<p>A microdeletion is the loss of a small section of <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a &ldquo;contiguous gene syndrome&rdquo;, as several neighbouring genes are affected by the loss of the <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/dna\/\" target=\"_self\" title=\"Deoxyribonucleic acid: biomolecule and carrier of genetic information\" class=\"encyclopedia\">DNA<\/a> segment.<\/p>\n<p>The best-known microdeletion syndromes are <a href=\"https:\/\/www.cenata.de\/en\/encyclopedia\/digeorge-syndrome\/\" target=\"_self\" title='DiGeorge syndrome is caused by a microscopically invisible loss (\"microdeletion\") of approximately 3 million bases (Mb) in chromosome 22. The clinical expression of DiGeorge syndrome varies depending on the amount of loss of genetic information and the area of the deletion.' class=\"encyclopedia\">DiGeorge syndrome<\/a>, Prader-Willi syndrome, Angelman syndrome, Williams syndrome and Wolf-Hirschhorn syndrome.<\/p>\n<p>Translated with www.DeepL.com\/Translator (free version)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A microdeletion is the loss of a small section of DNA that is not visible under the microscope. The loss typically comprises a few million bases and can only be detected with special techniques. In most cases, a microdeletion leads to a &#8220;contiguous gene syndrome&#8221;, as several neighbouring genes are affected by the loss of [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"class_list":["post-23354","encyclopedia","type-encyclopedia","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/encyclopedia\/23354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/encyclopedia"}],"about":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/types\/encyclopedia"}],"author":[{"embeddable":true,"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/users\/1"}],"wp:attachment":[{"href":"https:\/\/www.cenata.de\/en\/wp-json\/wp\/v2\/media?parent=23354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}