A mother’s blood contains both her own genetic information as well as that of her child, even in the early phases of pregnancy. This so-called “cell-free fetal DNA” (cffDNA) can now be tested for the presence of chromosomal disorders in the unborn child (e.g. trisomies) by means of a simple blood test for the mother.
Thanks to its unique test design, the Harmony® Test is very accurate and at the same time very reasonably priced. The detection rate for trisomy 21 is 99.5%, and the false-positive rate is only 0.06%. These figures were determined in a number of clinical studies involving approximately 30,000 pregnant women. These data, obtained with a previous version of the Harmony® Test (next generation sequencing), are fully transferable to the new microarray-based Harmony® Test, which has an even higher precision. A recent study of the Harmony® Test based on the microarray technology, shows a detection rate of >99 % for trisomy 21 and a detection of all trisomy 18 and 13 cases. There were no false-positive results.
Further details are available on the page Harmony® Test.
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